Human Gene BIK (ENST00000216115.3) from GENCODE V44
Description: Homo sapiens BCL2 interacting killer (BIK), mRNA. (from RefSeq NM_001197) RefSeq Summary (NM_001197): The protein encoded by this gene shares a critical BH3 domain with other death-promoting proteins, such as BID, BAK, BAD and BAX, that is required for its pro-apoptotic activity, and for interaction with anti-apoptotic members of the BCL2 family, and viral survival-promoting proteins. Since the activity of this protein is suppressed in the presence of survival-promoting proteins, it is suggested as a likely target for anti-apoptotic proteins. [provided by RefSeq, Sep 2011]. Gencode Transcript: ENST00000216115.3 Gencode Gene: ENSG00000100290.3 Transcript (Including UTRs) Position: hg38 chr22:43,110,750-43,129,712 Size: 18,963 Total Exon Count: 5 Strand: + Coding Region Position: hg38 chr22:43,124,023-43,129,305 Size: 5,283 Coding Exon Count: 4
ID:BIK_HUMAN DESCRIPTION: RecName: Full=Bcl-2-interacting killer; AltName: Full=Apoptosis inducer NBK; AltName: Full=BIP1; AltName: Full=BP4; FUNCTION: Accelerates programmed cell death. Association to the apoptosis repressors Bcl-X(L), BHRF1, Bcl-2 or its adenovirus homolog E1B 19k protein suppresses this death-promoting activity. Does not interact with BAX. SUBUNIT: Interacts with RHBDL4/RHBDD1. INTERACTION: P10415:BCL2; NbExp=3; IntAct=EBI-700794, EBI-77694; Q07817:BCL2L1; NbExp=2; IntAct=EBI-700794, EBI-78035; Q07817-1:BCL2L1; NbExp=3; IntAct=EBI-700794, EBI-287195; Q92843:BCL2L2; NbExp=2; IntAct=EBI-700794, EBI-707714; SUBCELLULAR LOCATION: Endomembrane system; Single-pass membrane protein. Mitochondrion membrane; Single-pass membrane protein (By similarity). Note=Around the nuclear envelope, and in cytoplasmic membranes. DOMAIN: Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family. PTM: Proteolytically cleaved by RHBDL4/RHBDD1. RHBDL4/RHBDD1- induced cleavage is a necessary step prior its degradation by the proteosome-dependent mechanism. WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/bik/";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q13323
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006915 apoptotic process GO:0008584 male gonad development GO:0032464 positive regulation of protein homooligomerization GO:0042981 regulation of apoptotic process GO:0090200 positive regulation of release of cytochrome c from mitochondria
US Server
