Human Gene NUP210 (ENST00000254508.7) from GENCODE V44
Description: Homo sapiens nucleoporin 210 (NUP210), mRNA. (from RefSeq NM_024923) RefSeq Summary (NM_024923): The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene is a membrane-spanning glycoprotein that is a major component of the nuclear pore complex. Multiple pseudogenes related to this gene are located on chromosome 3. [provided by RefSeq, Jul 2013]. Gencode Transcript: ENST00000254508.7 Gencode Gene: ENSG00000132182.13 Transcript (Including UTRs) Position: hg38 chr3:13,316,235-13,420,322 Size: 104,088 Total Exon Count: 40 Strand: - Coding Region Position: hg38 chr3:13,317,681-13,420,226 Size: 102,546 Coding Exon Count: 40
ID:PO210_HUMAN DESCRIPTION: RecName: Full=Nuclear pore membrane glycoprotein 210; Short=Nuclear pore protein gp210; AltName: Full=Nuclear envelope pore membrane protein POM 210; Short=POM210; AltName: Full=Nucleoporin Nup210; AltName: Full=Pore membrane protein of 210 kDa; Flags: Precursor; FUNCTION: Nucleoporin essential for nuclear pore assembly and fusion, nuclear pore spacing, as well as structural integrity. SUBUNIT: Forms dimers and possibly higher-order oligomers (By similarity). SUBCELLULAR LOCATION: Nucleus, nuclear pore complex. Nucleus membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. TISSUE SPECIFICITY: Ubiquitous expression, with highest levels in lung, liver, pancreas, testis, and ovary, intermediate levels in brain, kidney, and spleen, and lowest levels in heart and skeletal muscle. PTM: N-glycosylated, but not all potential glycosylation sites may be used. Contains high-mannose type oligosaccharides (By similarity). PTM: Phosphorylated at Ser-1881 in mitosis specifically; not phosphorylated in interphase (By similarity). MISCELLANEOUS: Recognized by antinuclear autoantibodies in primary biliary cirrhosis. MISCELLANEOUS: Knockdown of NUP210 causes nuclear membranes to accumulate aberrant structures termed twinned and fusion-arrested membranes and nuclear pore complex to cluster. Induces cell death and chromatin disruptions. SIMILARITY: Belongs to the NUP210 family. SEQUENCE CAUTION: Sequence=BAB15332.1; Type=Erroneous initiation; Sequence=BAC11688.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8TEM1
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.