Human Gene NUP210 (ENST00000254508.7) from GENCODE V44
  Description: Homo sapiens nucleoporin 210 (NUP210), mRNA. (from RefSeq NM_024923)
RefSeq Summary (NM_024923): The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene is a membrane-spanning glycoprotein that is a major component of the nuclear pore complex. Multiple pseudogenes related to this gene are located on chromosome 3. [provided by RefSeq, Jul 2013].
Gencode Transcript: ENST00000254508.7
Gencode Gene: ENSG00000132182.13
Transcript (Including UTRs)
   Position: hg38 chr3:13,316,235-13,420,322 Size: 104,088 Total Exon Count: 40 Strand: -
Coding Region
   Position: hg38 chr3:13,317,681-13,420,226 Size: 102,546 Coding Exon Count: 40 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr3:13,316,235-13,420,322)mRNA (may differ from genome)Protein (1887 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards
HGNCHPRDLynxMalacardsMGIneXtProt
OMIMPubMedReactomeUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: PO210_HUMAN
DESCRIPTION: RecName: Full=Nuclear pore membrane glycoprotein 210; Short=Nuclear pore protein gp210; AltName: Full=Nuclear envelope pore membrane protein POM 210; Short=POM210; AltName: Full=Nucleoporin Nup210; AltName: Full=Pore membrane protein of 210 kDa; Flags: Precursor;
FUNCTION: Nucleoporin essential for nuclear pore assembly and fusion, nuclear pore spacing, as well as structural integrity.
SUBUNIT: Forms dimers and possibly higher-order oligomers (By similarity).
SUBCELLULAR LOCATION: Nucleus, nuclear pore complex. Nucleus membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein.
TISSUE SPECIFICITY: Ubiquitous expression, with highest levels in lung, liver, pancreas, testis, and ovary, intermediate levels in brain, kidney, and spleen, and lowest levels in heart and skeletal muscle.
PTM: N-glycosylated, but not all potential glycosylation sites may be used. Contains high-mannose type oligosaccharides (By similarity).
PTM: Phosphorylated at Ser-1881 in mitosis specifically; not phosphorylated in interphase (By similarity).
MISCELLANEOUS: Recognized by antinuclear autoantibodies in primary biliary cirrhosis.
MISCELLANEOUS: Knockdown of NUP210 causes nuclear membranes to accumulate aberrant structures termed twinned and fusion-arrested membranes and nuclear pore complex to cluster. Induces cell death and chromatin disruptions.
SIMILARITY: Belongs to the NUP210 family.
SEQUENCE CAUTION: Sequence=BAB15332.1; Type=Erroneous initiation; Sequence=BAC11688.1; Type=Erroneous initiation;

-  Primer design for this transcript
 

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Click here to load the transcript sequence and exon structure into Primer3Plus

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Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: NUP210
Diseases sorted by gene-association score: primary biliary cirrhosis (15), autoimmune disease of urogenital tract (13), cholangitis, primary sclerosing (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 61.24 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 291.77 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -57.1096-0.595 Picture PostScript Text
3' UTR -552.401446-0.382 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR003343 - Big_2
IPR008964 - Invasin/intimin_cell_adhesion

Pfam Domains:
PF02368 - Bacterial Ig-like domain (group 2)

ModBase Predicted Comparative 3D Structure on Q8TEM1
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserGenome BrowserNo orthologGenome BrowserNo ortholog
Gene Details     
Gene Sorter     
MGIRGDEnsembl WormBase 
Protein SequenceProtein SequenceProtein Sequence Protein Sequence 
AlignmentAlignmentAlignment Alignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0046983 protein dimerization activity

Biological Process:
GO:0006406 mRNA export from nucleus
GO:0015031 protein transport
GO:0016032 viral process
GO:0051028 mRNA transport

Cellular Component:
GO:0005634 nucleus
GO:0005635 nuclear envelope
GO:0005643 nuclear pore
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0031965 nuclear membrane


-  Descriptions from all associated GenBank mRNAs
  LF384157 - JP 2014500723-A/191660: Polycomb-Associated Non-Coding RNAs.
MA619734 - JP 2018138019-A/191660: Polycomb-Associated Non-Coding RNAs.
AB384541 - Synthetic construct DNA, clone: pF1KA0906, Homo sapiens NUP210 gene for nucleoporin 210kDa, complete cds, without stop codon, in Flexi system.
AK026042 - Homo sapiens cDNA: FLJ22389 fis, clone HRC07681.
AK225409 - Homo sapiens mRNA for nucleoporin 210 variant, clone: HRC07681.
BC067089 - Homo sapiens nucleoporin 210kDa, mRNA (cDNA clone MGC:71114 IMAGE:6281693), complete cds.
BC020573 - Homo sapiens nucleoporin 210kDa, mRNA (cDNA clone IMAGE:4400434), with apparent retained intron.
KJ902306 - Synthetic construct Homo sapiens clone ccsbBroadEn_11700 NUP210 gene, encodes complete protein.
AL117527 - Homo sapiens mRNA; cDNA DKFZp434P1650 (from clone DKFZp434P1650).
AK075545 - Homo sapiens cDNA PSEC0245 fis, clone NT2RP3000719, highly similar to Nucleoporin 210.
AB020713 - Homo sapiens mRNA for KIAA0906 protein, partial cds.
JD063510 - Sequence 44534 from Patent EP1572962.
JD310913 - Sequence 291937 from Patent EP1572962.
JD057487 - Sequence 38511 from Patent EP1572962.
JD268002 - Sequence 249026 from Patent EP1572962.
AK074101 - Homo sapiens mRNA for FLJ00172 protein.
JD111108 - Sequence 92132 from Patent EP1572962.
JD189927 - Sequence 170951 from Patent EP1572962.
JD369431 - Sequence 350455 from Patent EP1572962.
JD516743 - Sequence 497767 from Patent EP1572962.
JD162339 - Sequence 143363 from Patent EP1572962.
JD467443 - Sequence 448467 from Patent EP1572962.
JD075803 - Sequence 56827 from Patent EP1572962.
JD272497 - Sequence 253521 from Patent EP1572962.
JD310258 - Sequence 291282 from Patent EP1572962.
JD229163 - Sequence 210187 from Patent EP1572962.
JD394097 - Sequence 375121 from Patent EP1572962.
JD404265 - Sequence 385289 from Patent EP1572962.
JD394915 - Sequence 375939 from Patent EP1572962.
JD205736 - Sequence 186760 from Patent EP1572962.
LF364082 - JP 2014500723-A/171585: Polycomb-Associated Non-Coding RNAs.
MA599659 - JP 2018138019-A/171585: Polycomb-Associated Non-Coding RNAs.
LF364083 - JP 2014500723-A/171586: Polycomb-Associated Non-Coding RNAs.
MA599660 - JP 2018138019-A/171586: Polycomb-Associated Non-Coding RNAs.
LF364084 - JP 2014500723-A/171587: Polycomb-Associated Non-Coding RNAs.
MA599661 - JP 2018138019-A/171587: Polycomb-Associated Non-Coding RNAs.
LF364085 - JP 2014500723-A/171588: Polycomb-Associated Non-Coding RNAs.
MA599662 - JP 2018138019-A/171588: Polycomb-Associated Non-Coding RNAs.
LF364087 - JP 2014500723-A/171590: Polycomb-Associated Non-Coding RNAs.
MA599664 - JP 2018138019-A/171590: Polycomb-Associated Non-Coding RNAs.
LF364088 - JP 2014500723-A/171591: Polycomb-Associated Non-Coding RNAs.
MA599665 - JP 2018138019-A/171591: Polycomb-Associated Non-Coding RNAs.
LF364089 - JP 2014500723-A/171592: Polycomb-Associated Non-Coding RNAs.
MA599666 - JP 2018138019-A/171592: Polycomb-Associated Non-Coding RNAs.
LF364090 - JP 2014500723-A/171593: Polycomb-Associated Non-Coding RNAs.
MA599667 - JP 2018138019-A/171593: Polycomb-Associated Non-Coding RNAs.
LF364095 - JP 2014500723-A/171598: Polycomb-Associated Non-Coding RNAs.
MA599672 - JP 2018138019-A/171598: Polycomb-Associated Non-Coding RNAs.
LF364096 - JP 2014500723-A/171599: Polycomb-Associated Non-Coding RNAs.
MA599673 - JP 2018138019-A/171599: Polycomb-Associated Non-Coding RNAs.
JD375145 - Sequence 356169 from Patent EP1572962.
JD515725 - Sequence 496749 from Patent EP1572962.
JD147803 - Sequence 128827 from Patent EP1572962.
BC068109 - Homo sapiens nucleoporin 210kDa, mRNA (cDNA clone IMAGE:6214700).
LF364099 - JP 2014500723-A/171602: Polycomb-Associated Non-Coding RNAs.
MA599676 - JP 2018138019-A/171602: Polycomb-Associated Non-Coding RNAs.
JD497106 - Sequence 478130 from Patent EP1572962.
LF364102 - JP 2014500723-A/171605: Polycomb-Associated Non-Coding RNAs.
MA599679 - JP 2018138019-A/171605: Polycomb-Associated Non-Coding RNAs.
JD341313 - Sequence 322337 from Patent EP1572962.
LF364104 - JP 2014500723-A/171607: Polycomb-Associated Non-Coding RNAs.
MA599681 - JP 2018138019-A/171607: Polycomb-Associated Non-Coding RNAs.
LF364108 - JP 2014500723-A/171611: Polycomb-Associated Non-Coding RNAs.
MA599685 - JP 2018138019-A/171611: Polycomb-Associated Non-Coding RNAs.
LF364109 - JP 2014500723-A/171612: Polycomb-Associated Non-Coding RNAs.
MA599686 - JP 2018138019-A/171612: Polycomb-Associated Non-Coding RNAs.
LF364110 - JP 2014500723-A/171613: Polycomb-Associated Non-Coding RNAs.
MA599687 - JP 2018138019-A/171613: Polycomb-Associated Non-Coding RNAs.
LF364114 - JP 2014500723-A/171617: Polycomb-Associated Non-Coding RNAs.
MA599691 - JP 2018138019-A/171617: Polycomb-Associated Non-Coding RNAs.
LF364117 - JP 2014500723-A/171620: Polycomb-Associated Non-Coding RNAs.
MA599694 - JP 2018138019-A/171620: Polycomb-Associated Non-Coding RNAs.
LF364120 - JP 2014500723-A/171623: Polycomb-Associated Non-Coding RNAs.
MA599697 - JP 2018138019-A/171623: Polycomb-Associated Non-Coding RNAs.
JD487857 - Sequence 468881 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  BioCarta from NCI Cancer Genome Anatomy Project
h_npcPathway - Mechanism of Protein Import into the Nucleus

Reactome (by CSHL, EBI, and GO)

Protein Q8TEM1 (Reactome details) participates in the following event(s):

R-HSA-75096 Docking of the TAP:EJC Complex with the NPC
R-HSA-165043 Rev multimer-bound HIV mRNA:Crm1:Ran:GTP complex associates with the NPC
R-HSA-180622 Vpr binds nucleoporins
R-HSA-180710 Rev:importin beta:B23 recruited to the nuclear pore
R-HSA-2990882 CDK1 phosphorylates NUP98
R-HSA-75098 mRNP complex dissociates from cytosolic face of NPC
R-HSA-165047 Translocation of nuclear RNA transport complex to cytoplasm
R-HSA-180732 Translocation of Rev:importin-beta:B23 to the nucleus
R-HSA-2990880 NEK6/NEK7 phosphorylates NUP98
R-HSA-170796 NPC transports GCK1:GKRP from cytosol to nucleoplasm
R-HSA-5578744 Importin-8 imports AGO2:miRNA into the nucleus
R-HSA-6783483 tRNA:XPOT:RAN:GTP translocates from the nucleus to the cytosol
R-HSA-3000348 RANBP2 SUMOylates SP100 with SUMO2
R-HSA-3000399 RANBP2 SUMOylates SP100 with SUMO1
R-HSA-3000411 RANBP2 SUMOylates PML with SUMO2
R-HSA-4570493 RANBP2 (NUP358) SUMOylates HNRNPC with SUMO1
R-HSA-4615872 RANBP2 SUMOylates HDAC4 with SUMO1
R-HSA-4615987 RANBP2 SUMOylates HDAC4 with SUMO2,3
R-HSA-5228508 RANBP2 SUMOylates PML with SUMO1
R-HSA-5228525 RANBP2 SUMOylates TOP2A with SUMO1
R-HSA-192627 Viral mRNA Export
R-HSA-192925 Export of Spliced Viral mRNA
R-HSA-5252041 NPC transports Hikeshi:HSP70s:ATP from cytosol to nucleoplasm
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript
R-HSA-165054 Rev-mediated nuclear export of HIV RNA
R-HSA-180910 Vpr-mediated nuclear import of PICs
R-HSA-180746 Nuclear import of Rev protein
R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly
R-HSA-72202 Transport of Mature Transcript to Cytoplasm
R-HSA-162599 Late Phase of HIV Life Cycle
R-HSA-177243 Interactions of Rev with host cellular proteins
R-HSA-176033 Interactions of Vpr with host cellular proteins
R-HSA-2980766 Nuclear Envelope Breakdown
R-HSA-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein
R-HSA-168276 NS1 Mediated Effects on Host Pathways
R-HSA-1169408 ISG15 antiviral mechanism
R-HSA-5578749 Transcriptional regulation by small RNAs
R-HSA-6784531 tRNA processing in the nucleus
R-HSA-3108214 SUMOylation of DNA damage response and repair proteins
R-HSA-4570464 SUMOylation of RNA binding proteins
R-HSA-4551638 SUMOylation of chromatin organization proteins
R-HSA-4615885 SUMOylation of DNA replication proteins
R-HSA-168325 Viral Messenger RNA Synthesis
R-HSA-3371453 Regulation of HSF1-mediated heat shock response
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA
R-HSA-162587 HIV Life Cycle
R-HSA-162909 Host Interactions of HIV factors
R-HSA-68875 Mitotic Prophase
R-HSA-70171 Glycolysis
R-HSA-168253 Host Interactions with Influenza Factors
R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes
R-HSA-211000 Gene Silencing by RNA
R-HSA-72306 tRNA processing
R-HSA-3108232 SUMO E3 ligases SUMOylate target proteins
R-HSA-168273 Influenza Viral RNA Transcription and Replication
R-HSA-3371556 Cellular response to heat stress
R-HSA-8953854 Metabolism of RNA
R-HSA-162906 HIV Infection
R-HSA-68886 M Phase
R-HSA-70326 Glucose metabolism
R-HSA-168254 Influenza Infection
R-HSA-913531 Interferon Signaling
R-HSA-74160 Gene expression (Transcription)
R-HSA-2990846 SUMOylation
R-HSA-168255 Influenza Life Cycle
R-HSA-2262752 Cellular responses to stress
R-HSA-5663205 Infectious disease
R-HSA-69278 Cell Cycle (Mitotic)
R-HSA-71387 Metabolism of carbohydrates
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-597592 Post-translational protein modification
R-HSA-8953897 Cellular responses to external stimuli
R-HSA-1643685 Disease
R-HSA-1640170 Cell Cycle
R-HSA-1430728 Metabolism
R-HSA-168256 Immune System
R-HSA-392499 Metabolism of proteins

-  Other Names for This Gene
  Alternate Gene Symbols: A6NN56, ENST00000254508.1, ENST00000254508.2, ENST00000254508.3, ENST00000254508.4, ENST00000254508.5, ENST00000254508.6, KIAA0906, NM_024923, O94980, PO210_HUMAN, PSEC0245, Q6NXG6, Q8NBJ1, Q8TEM1, Q9H6C8, Q9UFP3, uc003bxv.1, uc003bxv.2, uc003bxv.3, uc003bxv.4
UCSC ID: ENST00000254508.7
RefSeq Accession: NM_024923
Protein: Q8TEM1 (aka PO210_HUMAN)
CCDS: CCDS33704.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.