ID:OXSM_HUMAN DESCRIPTION: RecName: Full=3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial; EC=2.3.1.41; AltName: Full=Beta-ketoacyl-ACP synthase; Flags: Precursor; FUNCTION: May play a role in the biosynthesis of lipoic acid as well as longer chain fatty acids required for optimal mitochondrial function. CATALYTIC ACTIVITY: Acyl-[acyl-carrier-protein] + malonyl-[acyl- carrier-protein] = 3-oxoacyl-[acyl-carrier-protein] + CO(2) + [acyl-carrier-protein]. ENZYME REGULATION: Inhibited by cerulenin. BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=3.9 uM for C4-[acyl-carrier-protein]; KM=1.9 uM for C6-[acyl-carrier-protein]; KM=10.9 uM for C8-[acyl-carrier-protein]; KM=1.8 uM for C10-[acyl-carrier-protein]; KM=9.5 uM for C12-[acyl-carrier-protein]; KM=50.8 uM for C14-[acyl-carrier-protein]; Vmax=129 nmol/min/mg enzyme toward C4-[acyl-carrier-protein]; Vmax=241 nmol/min/mg enzyme toward C6-[acyl-carrier-protein]; Vmax=271 nmol/min/mg enzyme toward C8-[acyl-carrier-protein]; Vmax=364 nmol/min/mg enzyme toward C10-[acyl-carrier-protein]; Vmax=1045 nmol/min/mg enzyme toward C12-[acyl-carrier-protein]; Vmax=115 nmol/min/mg enzyme toward C14-[acyl-carrier-protein]; Note=The highest catalytic efficiency is observed for C10-[acyl- carrier-protein]; PATHWAY: Lipid metabolism; fatty acid biosynthesis. SUBCELLULAR LOCATION: Mitochondrion. TISSUE SPECIFICITY: Widely expressed. Higher expression in heart, skeletal muscle, liver and kidney which contain high levels of active mitochondria. SIMILARITY: Belongs to the beta-ketoacyl-ACP synthases family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9NWU1
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0003824 catalytic activity GO:0004315 3-oxoacyl-[acyl-carrier-protein] synthase activity GO:0016740 transferase activity GO:0016746 transferase activity, transferring acyl groups GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups
Biological Process: GO:0006629 lipid metabolic process GO:0006631 fatty acid metabolic process GO:0006633 fatty acid biosynthetic process GO:0006637 acyl-CoA metabolic process GO:0008152 metabolic process GO:0051790 short-chain fatty acid biosynthetic process GO:0051792 medium-chain fatty acid biosynthetic process