Human Gene ACKR2 (ENST00000422265.6) from GENCODE V44
Description: Homo sapiens atypical chemokine receptor 2 (ACKR2), mRNA. (from RefSeq NM_001296) RefSeq Summary (NM_001296): This gene encodes a beta chemokine receptor, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptor-mediated signal transduction are critical for the recruitment of effector immune cells to the inflammation site. This gene is expressed in a range of tissues and hemopoietic cells. The expression of this receptor in lymphatic endothelial cells and overexpression in vascular tumors suggested its function in chemokine-driven recirculation of leukocytes and possible chemokine effects on the development and growth of vascular tumors. This receptor appears to bind the majority of beta-chemokine family members; however, its specific function remains unknown. This gene is mapped to chromosome 3p21.3, a region that includes a cluster of chemokine receptor genes. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000422265.6 Gencode Gene: ENSG00000144648.16 Transcript (Including UTRs) Position: hg38 chr3:42,809,445-42,867,286 Size: 57,842 Total Exon Count: 3 Strand: + Coding Region Position: hg38 chr3:42,864,503-42,865,657 Size: 1,155 Coding Exon Count: 1
ID:CCBP2_HUMAN DESCRIPTION: RecName: Full=Chemokine-binding protein 2; AltName: Full=C-C chemokine receptor D6; AltName: Full=Chemokine receptor CCR-10; AltName: Full=Chemokine receptor CCR-9; AltName: Full=Chemokine-binding protein D6; FUNCTION: Receptor for C-C type chemokines including SCYA2/MCP-1, SCY3/MIP-1-alpha, SCYA5/RANTES and SCYA7/MCP-3. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Expressed primarily in placenta and fetal liver, and found at very low levels in the lung and lymph node. Found in endothelial cells lining afferent lymphatics in dermis and lymph nodes. Also found in lymph nodes subcapsular and medullary sinuses, tonsillar lymphatic sinuses and lymphatics in mucosa and submucosa of small and large intestine and appendix. Also found in some malignant vascular tumors. SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O00590
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
