Human Gene UQCRC1 (ENST00000203407.6) from GENCODE V44
  Description: Homo sapiens ubiquinol-cytochrome c reductase core protein 1 (UQCRC1), mRNA; nuclear gene for mitochondrial product. (from RefSeq NM_003365)
Gencode Transcript: ENST00000203407.6
Gencode Gene: ENSG00000010256.11
Transcript (Including UTRs)
   Position: hg38 chr3:48,599,002-48,609,646 Size: 10,645 Total Exon Count: 13 Strand: -
Coding Region
   Position: hg38 chr3:48,599,128-48,609,620 Size: 10,493 Coding Exon Count: 13 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr3:48,599,002-48,609,646)mRNA (may differ from genome)Protein (480 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards
HGNCHPRDLynxMalacardsMGIneXtProt
OMIMPubMedReactomeUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: QCR1_HUMAN
DESCRIPTION: RecName: Full=Cytochrome b-c1 complex subunit 1, mitochondrial; AltName: Full=Complex III subunit 1; AltName: Full=Core protein I; AltName: Full=Ubiquinol-cytochrome-c reductase complex core protein 1; Flags: Precursor;
FUNCTION: This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This protein may mediate formation of the complex between cytochromes c and c1.
SUBUNIT: The bc1 complex contains 11 subunits: 3 respiratory subunits (cytochrome b, cytochrome c1 and Rieske/UQCRFS1), 2 core proteins (UQCRC1/QCR1 and UQCRC2/QCR2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of Rieske/UQCRFS1).
SUBCELLULAR LOCATION: Mitochondrion inner membrane.
SIMILARITY: Belongs to the peptidase M16 family. UQCRC1/QCR1 subfamily.
CAUTION: Does not seem to have a protease activity as it lack the zinc-binding site.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 251.95 RPKM in Heart - Left Ventricle
Total median expression: 3425.10 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -4.8026-0.185 Picture PostScript Text
3' UTR -38.80126-0.308 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011249 - Metalloenz_metal-bd
IPR011237 - Pept_M16_core
IPR011765 - Pept_M16_N
IPR007863 - Peptidase_M16_C

Pfam Domains:
PF00675 - Insulinase (Peptidase family M16)
PF05193 - Peptidase M16 inactive domain

ModBase Predicted Comparative 3D Structure on P31930
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGDEnsembl   
Protein SequenceProtein SequenceProtein Sequence   
AlignmentAlignmentAlignment   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003824 catalytic activity
GO:0004222 metalloendopeptidase activity
GO:0008121 ubiquinol-cytochrome-c reductase activity
GO:0008270 zinc ion binding
GO:0031625 ubiquitin protein ligase binding
GO:0044877 macromolecular complex binding
GO:0046872 metal ion binding

Biological Process:
GO:0006119 oxidative phosphorylation
GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c
GO:0009060 aerobic respiration
GO:0014823 response to activity
GO:0016485 protein processing
GO:0043279 response to alkaloid
GO:0055114 oxidation-reduction process

Cellular Component:
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005746 mitochondrial respiratory chain
GO:0005750 mitochondrial respiratory chain complex III
GO:0005829 cytosol
GO:0016020 membrane
GO:0043209 myelin sheath
GO:0070469 respiratory chain


-  Descriptions from all associated GenBank mRNAs
  L16842 - Human ubiquinol cytochrome-c reductase core I protein mRNA, complete cds.
D26485 - Homo sapiens mRNA for core I protein, complete cds.
AK300694 - Homo sapiens cDNA FLJ51625 complete cds, highly similar to Ubiquinol-cytochrome-c reductase complex coreprotein I, mitochondrial precursor (EC 1.10.2.2).
AK129903 - Homo sapiens cDNA FLJ26393 fis, clone HRT07614, highly similar to Ubiquinol-cytochrome C reductase complex core protein I, mitochondrial precursor (EC 1.10.2.2).
BC009586 - Homo sapiens ubiquinol-cytochrome c reductase core protein I, mRNA (cDNA clone MGC:14649 IMAGE:4096628), complete cds.
JD326650 - Sequence 307674 from Patent EP1572962.
JD123218 - Sequence 104242 from Patent EP1572962.
JD114592 - Sequence 95616 from Patent EP1572962.
AK313090 - Homo sapiens cDNA, FLJ93573, highly similar to Homo sapiens ubiquinol-cytochrome c reductase core protein I(UQCRC1), mRNA.
AB590667 - Synthetic construct DNA, clone: pFN21AE1938, Homo sapiens UQCRC1 gene for ubiquinol-cytochrome c reductase core protein I, without stop codon, in Flexi system.
JD022529 - Sequence 3553 from Patent EP1572962.
AK302840 - Homo sapiens cDNA FLJ52292 complete cds, highly similar to Ubiquinol-cytochrome-c reductase complex coreprotein I, mitochondrial precursor (EC 1.10.2.2).

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa00190 - Oxidative phosphorylation
hsa01100 - Metabolic pathways
hsa04260 - Cardiac muscle contraction
hsa05010 - Alzheimer's disease
hsa05012 - Parkinson's disease
hsa05016 - Huntington's disease

BioCyc Knowledge Library
PWY-3781 - aerobic respiration I (cytochrome c)

BioCarta from NCI Cancer Genome Anatomy Project
h_etcPathway - Electron Transport Reaction in Mitochondria

Reactome (by CSHL, EBI, and GO)

Protein P31930 (Reactome details) participates in the following event(s):

R-HSA-164651 Electron transfer from ubiquinol to cytochrome c of complex III
R-HSA-611105 Respiratory electron transport
R-HSA-163200 Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
R-HSA-1428517 The citric acid (TCA) cycle and respiratory electron transport
R-HSA-1430728 Metabolism

-  Other Names for This Gene
  Alternate Gene Symbols: B2R7R8, ENST00000203407.1, ENST00000203407.2, ENST00000203407.3, ENST00000203407.4, ENST00000203407.5, NM_003365, P31930, Q96DD2, QCR1_HUMAN, uc003cub.1, uc003cub.2, uc003cub.3
UCSC ID: ENST00000203407.6
RefSeq Accession: NM_003365
Protein: P31930 (aka QCR1_HUMAN)
CCDS: CCDS2774.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.