Human Gene MON1A (ENST00000455683.7) from GENCODE V44
  Description: Homo sapiens MON1 homolog A, secretory trafficking associated (MON1A), transcript variant 2, mRNA. (from RefSeq NM_001142501)
Gencode Transcript: ENST00000455683.7
Gencode Gene: ENSG00000164077.15
Transcript (Including UTRs)
   Position: hg38 chr3:49,908,873-49,929,889 Size: 21,017 Total Exon Count: 5 Strand: -
Coding Region
   Position: hg38 chr3:49,909,014-49,913,346 Size: 4,333 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr3:49,908,873-49,929,889)mRNA (may differ from genome)Protein (393 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards
HGNCHPRDMalacardsMGIneXtProtOMIM
PubMedReactomeUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: MON1A_HUMAN
DESCRIPTION: RecName: Full=Vacuolar fusion protein MON1 homolog A;
FUNCTION: Plays an important in membrane trafficking through the secretory apparatus. Not involved in endocytic trafficking to lysosomes (By similarity).
SIMILARITY: Belongs to the MON1/SAND family.
SEQUENCE CAUTION: Sequence=AAH47022.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: MON1A
Diseases sorted by gene-association score: extrahepatic bile duct adenocarcinoma (2), space motion sickness (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 11.41 RPKM in Testis
Total median expression: 240.41 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -143.20294-0.487 Picture PostScript Text
3' UTR -49.20141-0.349 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR004353 - Vacuolar_fusion_protein_MON1

Pfam Domains:
PF03164 - Trafficking protein Mon1

ModBase Predicted Comparative 3D Structure on Q86VX9
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005515 protein binding

Biological Process:
GO:0009306 protein secretion
GO:0016192 vesicle-mediated transport

Cellular Component:
GO:0005829 cytosol
GO:0012505 endomembrane system
GO:0035658 Mon1-Ccz1 complex


-  Descriptions from all associated GenBank mRNAs
  BC009459 - Homo sapiens MON1 homolog A (yeast), mRNA (cDNA clone MGC:15935 IMAGE:3536968), complete cds.
BC047022 - Homo sapiens MON1 homolog A (yeast), mRNA (cDNA clone MGC:54100 IMAGE:5248424), complete cds.
AK074404 - Homo sapiens cDNA FLJ23824 fis, clone HUV00579.
BC006299 - Homo sapiens MON1 homolog A (yeast), mRNA (cDNA clone MGC:13272 IMAGE:4079816), complete cds.
AK092018 - Homo sapiens cDNA FLJ34699 fis, clone MESAN2002186.
AX747314 - Sequence 839 from Patent EP1308459.
JD356189 - Sequence 337213 from Patent EP1572962.
JD436851 - Sequence 417875 from Patent EP1572962.
AK315630 - Homo sapiens cDNA, FLJ96715.
KJ903413 - Synthetic construct Homo sapiens clone ccsbBroadEn_12807 MON1A gene, encodes complete protein.
CU692356 - Synthetic construct Homo sapiens gateway clone IMAGE:100021375 5' read MON1A mRNA.
AK307140 - Homo sapiens cDNA, FLJ97088.
JD119697 - Sequence 100721 from Patent EP1572962.
JD283557 - Sequence 264581 from Patent EP1572962.
JD282780 - Sequence 263804 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q86VX9 (Reactome details) participates in the following event(s):

R-HSA-8877451 MON1:CCZ1 exchanges GTP for GDP on RAB7
R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs
R-HSA-9007101 Rab regulation of trafficking
R-HSA-199991 Membrane Trafficking
R-HSA-5653656 Vesicle-mediated transport

-  Other Names for This Gene
  Alternate Gene Symbols: B2RDQ1, ENST00000455683.1, ENST00000455683.2, ENST00000455683.3, ENST00000455683.4, ENST00000455683.5, ENST00000455683.6, MON1A_HUMAN, NM_001142501, Q86VX9, Q8NAV7, Q9BRF3, SAND1, uc003cya.1, uc003cya.2, uc003cya.3, uc003cya.4, uc003cya.5
UCSC ID: ENST00000455683.7
RefSeq Accession: NM_001142501
Protein: Q86VX9 (aka MON1A_HUMAN)

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.