Human Gene PARP3 (ENST00000398755.8) from GENCODE V44
Description: Homo sapiens poly(ADP-ribose) polymerase family member 3 (PARP3), transcript variant 2, mRNA. (from RefSeq NM_005485) RefSeq Summary (NM_001003931): The protein encoded by this gene belongs to the PARP family. These enzymes modify nuclear proteins by poly-ADP-ribosylation, which is required for DNA repair, regulation of apoptosis, and maintenance of genomic stability. This gene encodes the poly(ADP-ribosyl)transferase 3, which is preferentially localized to the daughter centriole throughout the cell cycle. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000398755.8 Gencode Gene: ENSG00000041880.15 Transcript (Including UTRs) Position: hg38 chr3:51,942,363-51,948,867 Size: 6,505 Total Exon Count: 11 Strand: + Coding Region Position: hg38 chr3:51,943,356-51,948,480 Size: 5,125 Coding Exon Count: 10
ID:PARP3_HUMAN DESCRIPTION: RecName: Full=Poly [ADP-ribose] polymerase 3; Short=PARP-3; Short=hPARP-3; EC=2.4.2.30; AltName: Full=ADP-ribosyltransferase diphtheria toxin-like 3; Short=ARTD3; AltName: Full=IRT1; AltName: Full=NAD(+) ADP-ribosyltransferase 3; Short=ADPRT-3; AltName: Full=Poly[ADP-ribose] synthase 3; Short=pADPRT-3; FUNCTION: Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. May link the DNA damage surveillance network to the mitotic fidelity checkpoint. Negatively influences the G1/S cell cycle progression without interfering with centrosome duplication. Binds DNA. May be involved in the regulation of PRC2 and PRC3 complex-dependent gene silencing. CATALYTIC ACTIVITY: NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor. SUBUNIT: Interacts with PRKDC and PARP1. Interacts with XRCC5; the interaction is dependent on nucleic acids. Interacts with XRCC6; the interaction is dependent on nucleic acids. Interacts with EZH2, HDAC1, HDAC2, SUZ12, YY1, LRIG3 and LIG4. SUBCELLULAR LOCATION: Nucleus. Cytoplasm, cytoskeleton, centrosome. Cytoplasm, cytoskeleton, centrosome, centriole. Note=Core component of the centrosome. Preferentially localized to the daughter centriole throughout the cell cycle. According to PubMed:16924674, it is almost exclusively localized in the nucleus and appears in numerous small foci and a small number of larger foci whereas a centrosomal location has not been detected. TISSUE SPECIFICITY: Widely expressed; the highest levels are in the kidney, skeletal muscle, liver, heart and spleen; also detected in pancreas, lung, placenta, brain, leukocytes, colon, small intestine, ovary, testis, prostate and thymus. DOMAIN: According to PubMed:10329013, the N-terminal domain (54 amino acids) of isoform 2 is responsible for its centrosomal localization. The C-terminal region contains the catalytic domain. PTM: Auto-poly(ADP)-ribosylation. SIMILARITY: Contains 1 PARP alpha-helical domain. SIMILARITY: Contains 1 PARP catalytic domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9Y6F1
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0000723 telomere maintenance GO:0006273 lagging strand elongation GO:0006281 DNA repair GO:0006302 double-strand break repair GO:0006471 protein ADP-ribosylation GO:0051103 DNA ligation involved in DNA repair GO:0051106 positive regulation of DNA ligation GO:0060236 regulation of mitotic spindle organization GO:1905662 negative regulation of telomerase RNA reverse transcriptase activity GO:1990166 protein localization to site of double-strand break
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