Human Gene LRIG1 (ENST00000273261.8) from GENCODE V44
Description: Homo sapiens leucine rich repeats and immunoglobulin like domains 1 (LRIG1), transcript variant 1, mRNA. (from RefSeq NM_015541)
Gencode Transcript: ENST00000273261.8
Gencode Gene: ENSG00000144749.14
Transcript (Including UTRs)
Position: hg38 chr3:66,378,797-66,501,022 Size: 122,226 Total Exon Count: 19 Strand: -
Coding Region
Position: hg38 chr3:66,380,263-66,500,407 Size: 120,145 Coding Exon Count: 19
Data last updated at UCSC: 2023-08-18 00:09:47
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
ID: LRIG1_HUMAN
DESCRIPTION: RecName: Full=Leucine-rich repeats and immunoglobulin-like domains protein 1; Short=LIG-1; Flags: Precursor;
FUNCTION: Acts as a feedback negative regulator of signaling by receptor tyrosine kinases, through a mechanism that involves enhancement of receptor ubiquitination and accelerated intracellular degradation.SUBUNIT: Interacts with EGFR/ERBB1, ERBB2, ERBB3 and ERBB4.SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.TISSUE SPECIFICITY: Widely expressed.INDUCTION: By EGF.DOMAIN: The LRRs and the Ig-domains are each sufficient for EGFR/ERBB1 binding. This interaction is abolished only when these two domains are deleted.SIMILARITY: Contains 3 Ig-like C2-type (immunoglobulin-like) domains.SIMILARITY: Contains 15 LRR (leucine-rich) repeats.SIMILARITY: Contains 1 LRRCT domain.SIMILARITY: Contains 1 LRRNT domain.
Primer design for this transcript
MalaCards Disease Associations
Comparative Toxicogenomics Database (CTD)
RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR000483 - Cys-rich_flank_reg_C
IPR007110 - Ig-like
IPR013783 - Ig-like_fold
IPR013098 - Ig_I-set
IPR003599 - Ig_sub
IPR003598 - Ig_sub2
IPR001611 - Leu-rich_rpt
IPR003591 - Leu-rich_rpt_typical-subtyp
IPR000372 - LRR-contain_N
Pfam Domains: PF07679 - Immunoglobulin I-set domain
PF01463 - Leucine rich repeat C-terminal domain
ModBase Predicted Comparative 3D Structure on Q96JA1
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Descriptions from all associated GenBank mRNAs
LF207306 - JP 2014500723-A/14809: Polycomb-Associated Non-Coding RNAs.MA442883 - JP 2018138019-A/14809: Polycomb-Associated Non-Coding RNAs.AF381545 - Homo sapiens membrane glycoprotein LRIG1 (LRIG1) mRNA, complete cds.AY730707 - Homo sapiens leucine-rich repeat protein LRIG1 (LRIG1) mRNA, complete cds, alternatively spliced.AB050468 - Homo sapiens mRNA for membrane glycoprotein LIG-1, complete cds.BC071561 - Homo sapiens leucine-rich repeats and immunoglobulin-like domains 1, mRNA (cDNA clone MGC:87003 IMAGE:30340674), complete cds.BC140907 - Homo sapiens leucine-rich repeats and immunoglobulin-like domains 1, mRNA (cDNA clone MGC:176584 IMAGE:9056719), complete cds.AK314103 - Homo sapiens cDNA, FLJ94790.KJ902405 - Synthetic construct Homo sapiens clone ccsbBroadEn_11799 LRIG1 gene, encodes complete protein.BC014276 - Homo sapiens leucine-rich repeats and immunoglobulin-like domains 1, mRNA (cDNA clone IMAGE:3688299), partial cds.AL117666 - Homo sapiens mRNA; cDNA DKFZp586O1624 (from clone DKFZp586O1624); partial cds.AK126745 - Homo sapiens cDNA FLJ44791 fis, clone BRACE3039358, highly similar to Leucine-rich repeats and immunoglobulin-like domains protein 1 precursor.JD306147 - Sequence 287171 from Patent EP1572962.LF364412 - JP 2014500723-A/171915: Polycomb-Associated Non-Coding RNAs.MA599989 - JP 2018138019-A/171915: Polycomb-Associated Non-Coding RNAs.JD292627 - Sequence 273651 from Patent EP1572962.JD060310 - Sequence 41334 from Patent EP1572962.JD539049 - Sequence 520073 from Patent EP1572962.JD098133 - Sequence 79157 from Patent EP1572962.JD451018 - Sequence 432042 from Patent EP1572962.JD339137 - Sequence 320161 from Patent EP1572962.JD074016 - Sequence 55040 from Patent EP1572962.JD289736 - Sequence 270760 from Patent EP1572962.JD303830 - Sequence 284854 from Patent EP1572962.JD184669 - Sequence 165693 from Patent EP1572962.JD507437 - Sequence 488461 from Patent EP1572962.LF364413 - JP 2014500723-A/171916: Polycomb-Associated Non-Coding RNAs.MA599990 - JP 2018138019-A/171916: Polycomb-Associated Non-Coding RNAs.JD531968 - Sequence 512992 from Patent EP1572962.JD378319 - Sequence 359343 from Patent EP1572962.JD110345 - Sequence 91369 from Patent EP1572962.JD195549 - Sequence 176573 from Patent EP1572962.JD180088 - Sequence 161112 from Patent EP1572962.JD565459 - Sequence 546483 from Patent EP1572962.LF364414 - JP 2014500723-A/171917: Polycomb-Associated Non-Coding RNAs.MA599991 - JP 2018138019-A/171917: Polycomb-Associated Non-Coding RNAs.LF364415 - JP 2014500723-A/171918: Polycomb-Associated Non-Coding RNAs.MA599992 - JP 2018138019-A/171918: Polycomb-Associated Non-Coding RNAs.LF364416 - JP 2014500723-A/171919: Polycomb-Associated Non-Coding RNAs.MA599993 - JP 2018138019-A/171919: Polycomb-Associated Non-Coding RNAs.JD417562 - Sequence 398586 from Patent EP1572962.AK294984 - Homo sapiens cDNA FLJ50761 complete cds, highly similar to Leucine-rich repeats and immunoglobulin-like domains protein 1 precursor.LF364417 - JP 2014500723-A/171920: Polycomb-Associated Non-Coding RNAs.MA599994 - JP 2018138019-A/171920: Polycomb-Associated Non-Coding RNAs.LF364418 - JP 2014500723-A/171921: Polycomb-Associated Non-Coding RNAs.MA599995 - JP 2018138019-A/171921: Polycomb-Associated Non-Coding RNAs.LF364419 - JP 2014500723-A/171922: Polycomb-Associated Non-Coding RNAs.MA599996 - JP 2018138019-A/171922: Polycomb-Associated Non-Coding RNAs.LF364420 - JP 2014500723-A/171923: Polycomb-Associated Non-Coding RNAs.MA599997 - JP 2018138019-A/171923: Polycomb-Associated Non-Coding RNAs.LF364421 - JP 2014500723-A/171924: Polycomb-Associated Non-Coding RNAs.MA599998 - JP 2018138019-A/171924: Polycomb-Associated Non-Coding RNAs.LF364422 - JP 2014500723-A/171925: Polycomb-Associated Non-Coding RNAs.MA599999 - JP 2018138019-A/171925: Polycomb-Associated Non-Coding RNAs.LF364423 - JP 2014500723-A/171926: Polycomb-Associated Non-Coding RNAs.MA600000 - JP 2018138019-A/171926: Polycomb-Associated Non-Coding RNAs.LF364424 - JP 2014500723-A/171927: Polycomb-Associated Non-Coding RNAs.MA600001 - JP 2018138019-A/171927: Polycomb-Associated Non-Coding RNAs.LF364425 - JP 2014500723-A/171928: Polycomb-Associated Non-Coding RNAs.MA600002 - JP 2018138019-A/171928: Polycomb-Associated Non-Coding RNAs.LF364427 - JP 2014500723-A/171930: Polycomb-Associated Non-Coding RNAs.MA600004 - JP 2018138019-A/171930: Polycomb-Associated Non-Coding RNAs.LF364429 - JP 2014500723-A/171932: Polycomb-Associated Non-Coding RNAs.MA600006 - JP 2018138019-A/171932: Polycomb-Associated Non-Coding RNAs.LF364435 - JP 2014500723-A/171938: Polycomb-Associated Non-Coding RNAs.MA600012 - JP 2018138019-A/171938: Polycomb-Associated Non-Coding RNAs.LF212067 - JP 2014500723-A/19570: Polycomb-Associated Non-Coding RNAs.MA447644 - JP 2018138019-A/19570: Polycomb-Associated Non-Coding RNAs.JD445760 - Sequence 426784 from Patent EP1572962.JD468646 - Sequence 449670 from Patent EP1572962.JD368693 - Sequence 349717 from Patent EP1572962.JD159376 - Sequence 140400 from Patent EP1572962.
Biochemical and Signaling Pathways
Other Names for This Gene
Alternate Gene Symbols: ENST00000273261.1, ENST00000273261.2, ENST00000273261.3, ENST00000273261.4, ENST00000273261.5, ENST00000273261.6, ENST00000273261.7, LIG1, LRIG1_HUMAN, NM_015541, Q6IQ51, Q96CF9, Q96JA1, Q9BYB8, Q9UFI4, uc003dmx.1, uc003dmx.2, uc003dmx.3, uc003dmx.4, uc003dmx.5UCSC ID: ENST00000273261.8RefSeq Accession: NM_015541
Protein: Q96JA1
(aka LRIG1_HUMAN or LIG1_HUMAN)
CCDS: CCDS33783.1
Methods, Credits, and Use Restrictions
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