Human Gene TOMM70 (ENST00000284320.6) from GENCODE V44
Description: Homo sapiens translocase of outer mitochondrial membrane 70 (TOMM70), mRNA; nuclear gene for mitochondrial product. (from RefSeq NM_014820) RefSeq Summary (NM_014820): This gene encodes an import receptor of the outer mitochondrial membrane that is part of the translocase of the outer membrane complex. This protein is involved in the import of mitochondrial precursor proteins. [provided by RefSeq, Oct 2011]. Gencode Transcript: ENST00000284320.6 Gencode Gene: ENSG00000154174.8 Transcript (Including UTRs) Position: hg38 chr3:100,363,431-100,401,089 Size: 37,659 Total Exon Count: 12 Strand: - Coding Region Position: hg38 chr3:100,365,564-100,400,949 Size: 35,386 Coding Exon Count: 12
ID:TOM70_HUMAN DESCRIPTION: RecName: Full=Mitochondrial import receptor subunit TOM70; AltName: Full=Mitochondrial precursor proteins import receptor; AltName: Full=Translocase of outer membrane 70 kDa subunit; FUNCTION: Receptor that accelerates the import of all mitochondrial precursor proteins (By similarity). SUBUNIT: Forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) which consists of at least 7 different proteins (TOMM5, TOMM6, TOMM7, TOMM20, TOMM22, TOMM40 and TOMM70). Interacts with CAPN8 (By similarity). SUBCELLULAR LOCATION: Mitochondrion outer membrane; Single-pass membrane protein (By similarity). SIMILARITY: Belongs to the Tom70 family. SIMILARITY: Contains 10 TPR repeats. SEQUENCE CAUTION: Sequence=BAA34439.2; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O94826
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.