Human Gene TRMT10C (ENST00000309922.7) from GENCODE V44
Description: Homo sapiens tRNA methyltransferase 10C, mitochondrial RNase P subunit (TRMT10C), mRNA. (from RefSeq NM_017819) RefSeq Summary (NM_017819): This gene encodes the precursor of a subunit of the mitochondrial ribonuclease P, which is involved in 5' processing of mitochondrial tRNAs. The encoded protein may confer RNA-binding capacity to mitochondrial ribonuclease P and may be essential for transcript processing, RNA modification, translation and mitochondrial respiration. [provided by RefSeq, Nov 2012]. Gencode Transcript: ENST00000309922.7 Gencode Gene: ENSG00000174173.7 Transcript (Including UTRs) Position: hg38 chr3:101,561,868-101,566,446 Size: 4,579 Total Exon Count: 2 Strand: + Coding Region Position: hg38 chr3:101,564,782-101,565,993 Size: 1,212 Coding Exon Count: 1
ID:MRRP1_HUMAN DESCRIPTION: RecName: Full=Mitochondrial ribonuclease P protein 1; Short=Mitochondrial RNase P protein 1; EC=2.1.1.-; AltName: Full=HBV pre-S2 trans-regulated protein 2; AltName: Full=RNA (guanine-9-)-methyltransferase domain-containing protein 1; AltName: Full=Renal carcinoma antigen NY-REN-49; AltName: Full=tRNA methyltransferase 10 homolog C; Flags: Precursor; FUNCTION: Functions in mitochondrial tRNA maturation. Part of mitochondrial ribonuclease P, an enzyme composed of MRPP1/RG9MTD1, MRPP2/HSD17B10 and MRPP3/KIAA0391, which cleaves tRNA molecules in their 5'-ends. SUBUNIT: Interacts with MRPP2/HSD17B10 and MRPP3/KIAA0391. INTERACTION: Q99714:HSD17B10; NbExp=4; IntAct=EBI-2107046, EBI-79964; SUBCELLULAR LOCATION: Mitochondrion. SIMILARITY: Belongs to the RNA methyltransferase TrmD family. TRM10 subfamily. CAUTION: It is uncertain whether Met-1 or Met-7 is the initiator. SEQUENCE CAUTION: Sequence=AAD42877.1; Type=Erroneous initiation; Sequence=AAH35967.2; Type=Erroneous initiation; Sequence=BAA91166.1; Type=Frameshift; Positions=128;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q7L0Y3
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
BC035967 - Homo sapiens RNA (guanine-9-) methyltransferase domain containing 1, mRNA (cDNA clone MGC:32567 IMAGE:4719195), complete cds. AF226052 - Homo sapiens HNYA (HNYA) mRNA, complete cds. AK000439 - Homo sapiens cDNA FLJ20432 fis, clone KAT03764. JD232198 - Sequence 213222 from Patent EP1572962. AF086243 - Homo sapiens full length insert cDNA clone ZD37F12. AF155111 - Homo sapiens NY-REN-49 antigen mRNA, partial cds. JD558991 - Sequence 540015 from Patent EP1572962. JD461386 - Sequence 442410 from Patent EP1572962. JD323970 - Sequence 304994 from Patent EP1572962. JD465685 - Sequence 446709 from Patent EP1572962. CU690234 - Synthetic construct Homo sapiens gateway clone IMAGE:100022272 5' read RG9MTD1 mRNA. HQ447662 - Synthetic construct Homo sapiens clone IMAGE:100071008; CCSB013205_03 RNA (guanine-9-) methyltransferase domain containing 1 (RG9MTD1) gene, encodes complete protein. KJ902719 - Synthetic construct Homo sapiens clone ccsbBroadEn_12113 RG9MTD1 gene, encodes complete protein. AY561707 - Homo sapiens HBV pre-S2 trans-regulated protein 2 mRNA, complete cds. JD323656 - Sequence 304680 from Patent EP1572962. JD287281 - Sequence 268305 from Patent EP1572962. JD374712 - Sequence 355736 from Patent EP1572962. JD163060 - Sequence 144084 from Patent EP1572962. JD082646 - Sequence 63670 from Patent EP1572962. JD112762 - Sequence 93786 from Patent EP1572962. JD523876 - Sequence 504900 from Patent EP1572962. JD500090 - Sequence 481114 from Patent EP1572962. AK026532 - Homo sapiens cDNA: FLJ22879 fis, clone KAT03544. JD260129 - Sequence 241153 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q7L0Y3 (Reactome details) participates in the following event(s):
R-HSA-6787594 TRMT10C:HSD17B10 (TRMT10C:SDR5C1) methylates adenosine-9 in tRNA yielding 1-methyladenosine-9 R-HSA-6787591 TRMT10C:HSD17B10 (TRMT10C:SDR5C1) of mitochondrial RNase P methylates guanosine-9 in tRNA yielding 1-methylguanosine-9 R-HSA-6785470 tRNA processing in the mitochondrion R-HSA-8868766 rRNA processing in the mitochondrion R-HSA-6787450 tRNA modification in the mitochondrion R-HSA-72306 tRNA processing R-HSA-72312 rRNA processing R-HSA-8953854 Metabolism of RNA