Human Gene NR1I2 (ENST00000393716.8) from GENCODE V44
Description: Homo sapiens nuclear receptor subfamily 1 group I member 2 (NR1I2), transcript variant 1, mRNA. (from RefSeq NM_003889) RefSeq Summary (NM_003889): This gene product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. Several alternatively spliced transcripts encoding different isoforms, some of which use non-AUG (CUG) translation initiation codon, have been described for this gene. Additional transcript variants exist, however, they have not been fully characterized. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000393716.8 Gencode Gene: ENSG00000144852.20 Transcript (Including UTRs) Position: hg38 chr3:119,782,101-119,818,487 Size: 36,387 Total Exon Count: 9 Strand: + Coding Region Position: hg38 chr3:119,807,251-119,817,212 Size: 9,962 Coding Exon Count: 8
ID:NR1I2_HUMAN DESCRIPTION: RecName: Full=Nuclear receptor subfamily 1 group I member 2; AltName: Full=Orphan nuclear receptor PAR1; AltName: Full=Orphan nuclear receptor PXR; AltName: Full=Pregnane X receptor; AltName: Full=Steroid and xenobiotic receptor; Short=SXR; FUNCTION: Nuclear receptor that binds and is activated by variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, drugs and endogenous compounds. Activated by the antibiotic rifampicin and various plant metabolites, such as hyperforin, guggulipid, colupulone, and isoflavones. Response to specific ligands is species-specific. Activated by naturally occurring steroids, such as pregnenolone and progesterone. Binds to a response element in the promoters of the CYP3A4 and ABCB1/MDR1 genes. SUBUNIT: Heterodimer with RXR. Interacts with NCOA1. SUBCELLULAR LOCATION: Nucleus. TISSUE SPECIFICITY: Expressed in liver, colon and small intestine. SIMILARITY: Belongs to the nuclear hormone receptor family. NR1 subfamily. SIMILARITY: Contains 1 nuclear receptor DNA-binding domain. WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/nr1i2/";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O75469
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding GO:0003677 DNA binding GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0003707 steroid hormone receptor activity GO:0003713 transcription coactivator activity GO:0004879 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding GO:0005515 protein binding GO:0008144 drug binding GO:0008270 zinc ion binding GO:0043565 sequence-specific DNA binding GO:0046872 metal ion binding
Biological Process: GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006367 transcription initiation from RNA polymerase II promoter GO:0006805 xenobiotic metabolic process GO:0007165 signal transduction GO:0008202 steroid metabolic process GO:0010628 positive regulation of gene expression GO:0030522 intracellular receptor signaling pathway GO:0042738 exogenous drug catabolic process GO:0042908 xenobiotic transport GO:0043401 steroid hormone mediated signaling pathway GO:0045892 negative regulation of transcription, DNA-templated GO:0045893 positive regulation of transcription, DNA-templated GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0046618 drug export
AJ009936 - Homo sapiens mRNA for nuclear hormone receptor PRR1. AJ009937 - Homo sapiens mRNA for nuclear hormone receptor PRR2. AY091855 - Homo sapiens steroid and xenobiotic sensing nuclear receptor SXR (NR1I2) mRNA, complete cds. AF061056 - Homo sapiens orphan nuclear receptor PXR mRNA, complete cds. AK310789 - Homo sapiens cDNA, FLJ17831. AK223456 - Homo sapiens mRNA, Splice isoform 1C of O75469 variant, clone: FCC115A09. AF084645 - Homo sapiens orphan nuclear receptor (PAR1) mRNA, complete cds. BC017304 - Homo sapiens nuclear receptor subfamily 1, group I, member 2, mRNA (cDNA clone MGC:29598 IMAGE:5087401), complete cds. AF084644 - Homo sapiens orphan nuclear receptor (PAR2) mRNA, complete cds. AB528010 - Synthetic construct DNA, clone: pF1KB7714, Homo sapiens NR1I2 gene for nuclear receptor subfamily 1, group I, member 2, without stop codon, in Flexi system. HQ692837 - Homo sapiens pregnane X nuclear receptor variant 2 (NR1i2) mRNA, complete cds. HQ709177 - Homo sapiens pregnane X nuclear receptor (NR1I2) mRNA, complete cds. JD142446 - Sequence 123470 from Patent EP1572962. JD256139 - Sequence 237163 from Patent EP1572962. JD056332 - Sequence 37356 from Patent EP1572962. JD080010 - Sequence 61034 from Patent EP1572962. AB307701 - Homo sapiens NR1I2 mRNA for orphan nuclear receptor PXR, complete cds. CU677901 - Synthetic construct Homo sapiens gateway clone IMAGE:100017628 5' read NR1I2 mRNA. KJ901918 - Synthetic construct Homo sapiens clone ccsbBroadEn_11312 NR1I2 gene, encodes complete protein. KR710565 - Synthetic construct Homo sapiens clone CCSBHm_00014073 NR1I2 (NR1I2) mRNA, encodes complete protein. KR710566 - Synthetic construct Homo sapiens clone CCSBHm_00014074 NR1I2 (NR1I2) mRNA, encodes complete protein. KR710567 - Synthetic construct Homo sapiens clone CCSBHm_00014076 NR1I2 (NR1I2) mRNA, encodes complete protein. KR710568 - Synthetic construct Homo sapiens clone CCSBHm_00014078 NR1I2 (NR1I2) mRNA, encodes complete protein. AK122990 - Homo sapiens cDNA FLJ16751 fis, clone BEAST2001444, highly similar to Orphan nuclear receptor PXR. JD403439 - Sequence 384463 from Patent EP1572962. JD125827 - Sequence 106851 from Patent EP1572962. JD369530 - Sequence 350554 from Patent EP1572962. JD159717 - Sequence 140741 from Patent EP1572962. JD429258 - Sequence 410282 from Patent EP1572962. JD347419 - Sequence 328443 from Patent EP1572962. JD289228 - Sequence 270252 from Patent EP1572962. JD325502 - Sequence 306526 from Patent EP1572962. JD266795 - Sequence 247819 from Patent EP1572962. JD176689 - Sequence 157713 from Patent EP1572962. JD140719 - Sequence 121743 from Patent EP1572962. JD204462 - Sequence 185486 from Patent EP1572962. JD435256 - Sequence 416280 from Patent EP1572962.
Biochemical and Signaling Pathways
BioCarta from NCI Cancer Genome Anatomy Project h_th1th2Pathway - Th1/Th2 Differentiation h_nuclearRsPathway - Nuclear Receptors in Lipid Metabolism and Toxicity
Reactome (by CSHL, EBI, and GO)
Protein O75469 (Reactome details) participates in the following event(s):
US Server
