Human Gene OSBPL11 (ENST00000296220.6) from GENCODE V44
  Description: Homo sapiens oxysterol binding protein like 11 (OSBPL11), mRNA. (from RefSeq NM_022776)
RefSeq Summary (NM_022776): This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Like most members, the encoded protein contains an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. [provided by RefSeq, Jul 2008].
Gencode Transcript: ENST00000296220.6
Gencode Gene: ENSG00000144909.8
Transcript (Including UTRs)
   Position: hg38 chr3:125,528,858-125,595,497 Size: 66,640 Total Exon Count: 13 Strand: -
Coding Region
   Position: hg38 chr3:125,530,515-125,594,800 Size: 64,286 Coding Exon Count: 13 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr3:125,528,858-125,595,497)mRNA (may differ from genome)Protein (747 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards
HGNCHPRDLynxMalacardsMGIneXtProt
OMIMPubMedUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: OSB11_HUMAN
DESCRIPTION: RecName: Full=Oxysterol-binding protein-related protein 11; Short=ORP-11; Short=OSBP-related protein 11;
TISSUE SPECIFICITY: Widely expressed.
SIMILARITY: Belongs to the OSBP family.
SIMILARITY: Contains 1 PH domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 21.01 RPKM in Muscle - Skeletal
Total median expression: 254.76 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -275.00697-0.395 Picture PostScript Text
3' UTR -366.401657-0.221 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000648 - Oxysterol-bd
IPR018494 - Oxysterol-bd_CS
IPR011993 - PH_like_dom
IPR001849 - Pleckstrin_homology

Pfam Domains:
PF01237 - Oxysterol-binding protein
PF00169 - PH domain

Protein Data Bank (PDB) 3-D Structure
MuPIT help
2D9X - NMR MuPIT


ModBase Predicted Comparative 3D Structure on Q9BXB4
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserGenome BrowserNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGDEnsembl   
Protein SequenceProtein SequenceProtein Sequence   
AlignmentAlignmentAlignment   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0008289 lipid binding

Biological Process:
GO:0006869 lipid transport
GO:0010890 positive regulation of sequestering of triglyceride
GO:0045444 fat cell differentiation

Cellular Component:
GO:0005654 nucleoplasm
GO:0005768 endosome
GO:0005794 Golgi apparatus
GO:0016020 membrane
GO:0031902 late endosome membrane


-  Descriptions from all associated GenBank mRNAs
  BC010422 - Homo sapiens oxysterol binding protein-like 11, mRNA (cDNA clone IMAGE:3028650), complete cds.
BC065213 - Homo sapiens oxysterol binding protein-like 11, mRNA (cDNA clone MGC:74549 IMAGE:3916115), complete cds.
AK023226 - Homo sapiens cDNA FLJ13164 fis, clone NT2RP3003659, weakly similar to HES1 PROTEIN.
AF392454 - Homo sapiens oxysterol-binding protein-like protein OSBPL11 (OSBPL11) mRNA, complete cds.
AK292702 - Homo sapiens cDNA FLJ76960 complete cds, highly similar to Homo sapiens oxysterol binding protein-like 11 (OSBPL11), mRNA.
HM005445 - Homo sapiens clone HTL-T-132 testicular tissue protein Li 132 mRNA, complete cds.
EU831807 - Synthetic construct Homo sapiens clone HAIB:100066836; DKFZo008F0321 oxysterol binding protein-like 11 protein (OSBPL11) gene, encodes complete protein.
EU831884 - Synthetic construct Homo sapiens clone HAIB:100066913; DKFZo004F0322 oxysterol binding protein-like 11 protein (OSBPL11) gene, encodes complete protein.
AB384762 - Synthetic construct DNA, clone: pF1KB3224, Homo sapiens OSBPL11 gene for oxysterol-binding protein-related protein 11, complete cds, without stop codon, in Flexi system.
AF346292 - Homo sapiens OSBP related protein 11 mRNA, partial cds.
AY007102 - Homo sapiens clone TCCCIA00292 mRNA sequence.
JD566277 - Sequence 547301 from Patent EP1572962.
JD113956 - Sequence 94980 from Patent EP1572962.
JD243927 - Sequence 224951 from Patent EP1572962.
AK023074 - Homo sapiens cDNA FLJ13012 fis, clone NT2RP3000578, weakly similar to HES1 PROTEIN.
JD382009 - Sequence 363033 from Patent EP1572962.
JD267814 - Sequence 248838 from Patent EP1572962.
JD245558 - Sequence 226582 from Patent EP1572962.
JD065603 - Sequence 46627 from Patent EP1572962.
JD178034 - Sequence 159058 from Patent EP1572962.
JD040705 - Sequence 21729 from Patent EP1572962.
JD556944 - Sequence 537968 from Patent EP1572962.
JD081993 - Sequence 63017 from Patent EP1572962.
JD369254 - Sequence 350278 from Patent EP1572962.
JD181911 - Sequence 162935 from Patent EP1572962.
JD534322 - Sequence 515346 from Patent EP1572962.
JD253512 - Sequence 234536 from Patent EP1572962.
JD084005 - Sequence 65029 from Patent EP1572962.
JD224501 - Sequence 205525 from Patent EP1572962.
JD530982 - Sequence 512006 from Patent EP1572962.
JD145954 - Sequence 126978 from Patent EP1572962.
JD266820 - Sequence 247844 from Patent EP1572962.
JD292608 - Sequence 273632 from Patent EP1572962.
JD250504 - Sequence 231528 from Patent EP1572962.
JD094624 - Sequence 75648 from Patent EP1572962.
JD094623 - Sequence 75647 from Patent EP1572962.
JD314913 - Sequence 295937 from Patent EP1572962.
JF432682 - Synthetic construct Homo sapiens clone IMAGE:100073920 oxysterol binding protein-like 11 (OSBPL11) gene, encodes complete protein.
KJ903648 - Synthetic construct Homo sapiens clone ccsbBroadEn_13042 OSBPL11 gene, encodes complete protein.
JD516124 - Sequence 497148 from Patent EP1572962.
AF318344 - Homo sapiens pp14733 mRNA, complete cds.
JD435227 - Sequence 416251 from Patent EP1572962.
JD172107 - Sequence 153131 from Patent EP1572962.
JD394548 - Sequence 375572 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: A8K9I7, ENST00000296220.1, ENST00000296220.2, ENST00000296220.3, ENST00000296220.4, ENST00000296220.5, NM_022776, ORP11, OSB11_HUMAN, OSBP12, Q9BXB4, uc003eic.1, uc003eic.2, uc003eic.3, uc003eic.4, uc003eic.5
UCSC ID: ENST00000296220.6
RefSeq Accession: NM_022776
Protein: Q9BXB4 (aka OSB11_HUMAN)
CCDS: CCDS3033.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.