Human Gene NEK11 (ENST00000511262.5) from GENCODE V44
Description: Homo sapiens NIMA related kinase 11 (NEK11), transcript variant 2, mRNA. (from RefSeq NM_145910) RefSeq Summary (NM_145910): This gene encodes a member of the never in mitosis gene A family of kinases. The encoded protein localizes to the nucleoli, and may function with NEK2A in the S-phase checkpoint. The encoded protein appears to play roles in DNA replication and response to genotoxic stress. Alternatively spliced transcript variants have been described.[provided by RefSeq, Mar 2009]. Gencode Transcript: ENST00000511262.5 Gencode Gene: ENSG00000114670.14 Transcript (Including UTRs) Position: hg38 chr3:131,026,883-131,175,130 Size: 148,248 Total Exon Count: 15 Strand: + Coding Region Position: hg38 chr3:131,029,709-131,174,780 Size: 145,072 Coding Exon Count: 13
ID:NEK11_HUMAN DESCRIPTION: RecName: Full=Serine/threonine-protein kinase Nek11; EC=2.7.11.1; AltName: Full=Never in mitosis A-related kinase 11; Short=NimA-related protein kinase 11; FUNCTION: Protein kinase which plays an important role in the G2/M checkpoint response to DNA damage. Controls degradation of CDC25A by directly phosphorylating it on residues whose phosphorylation is required for BTRC-mediated polyubiquitination and degradation. CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein. COFACTOR: Manganese or magnesium. ENZYME REGULATION: Autorepressed by intramolecular binding of the C-terminus which dissociates following phosphorylation by NEK2 isoform 1 in G1/S-arrested cells. NEK2 isoform 2 is largely not present in the nucleolus, and does not appear to phosphorylate NEK11. Activated in response to DNA damage. Inhibited by zinc. SUBUNIT: Interacts with isoform 1 of NEK2. INTERACTION: P51955:NEK2; NbExp=5; IntAct=EBI-633195, EBI-633182; P51955-1:NEK2; NbExp=2; IntAct=EBI-633195, EBI-687792; SUBCELLULAR LOCATION: Nucleus. Nucleus, nucleolus. Note=Nuclear during interphase but moves to the polar microtubules during prometaphase and metaphase. Accumulates in the nucleolus in G1/S- arrested cells. TISSUE SPECIFICITY: Poorly expressed in cerebellum, trachea, lung, appendix, and uterus. DEVELOPMENTAL STAGE: Predominantly expressed at S/G2/M phase. PTM: Phosphorylated by NEK2. Phosphorylation at Ser-273 is important for its activation. SIMILARITY: Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily. SIMILARITY: Contains 1 protein kinase domain. SEQUENCE CAUTION: Sequence=BAB15672.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8NG66
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
