Human Gene RNF13 (ENST00000344229.7) from GENCODE V44
Description: Homo sapiens ring finger protein 13 (RNF13), transcript variant 1, mRNA. (from RefSeq NM_007282) RefSeq Summary (NM_007282): The protein encoded by this gene contains a RING zinc finger, a motif known to be involved in protein-protein interactions. The specific function of this gene has not yet been determined. Alternatively spliced transcript variants that encode the same protein have been reported. A pseudogene, which is also located on chromosome 3, has been defined for this gene. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000344229.7 Gencode Gene: ENSG00000082996.20 Transcript (Including UTRs) Position: hg38 chr3:149,812,770-149,962,122 Size: 149,353 Total Exon Count: 11 Strand: + Coding Region Position: hg38 chr3:149,846,027-149,961,104 Size: 115,078 Coding Exon Count: 9
ID:RNF13_HUMAN DESCRIPTION: RecName: Full=E3 ubiquitin-protein ligase RNF13; EC=6.3.2.-; AltName: Full=RING finger protein 13; Flags: Precursor; FUNCTION: E3 ubiquitin-protein ligase that may play a role in controlling cell proliferation. PATHWAY: Protein modification; protein ubiquitination. SUBCELLULAR LOCATION: Endoplasmic reticulum membrane. Golgi apparatus membrane. Late endosome membrane; Single-pass membrane protein (By similarity). Lysosome membrane. Nucleus inner membrane (By similarity). Note=Under certain conditions, relocalizes to recycling endosomes and to the inner nuclear membrane (By similarity). TISSUE SPECIFICITY: Widely expressed (at protein level). In normal pancreas, expressed in islets, but not in ducts, nor in acini (at protein level). DOMAIN: The RING-type zinc finger domain is required for E3 ligase activity. PTM: Auto-ubiquitinated. SIMILARITY: Contains 1 PA (protease associated) domain. SIMILARITY: Contains 1 RING-type zinc finger.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF02225 - PA domain PF13639 - Ring finger domain
ModBase Predicted Comparative 3D Structure on O43567
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Microarray Expression Data 
