Human Gene TIPARP (ENST00000295924.12) from GENCODE V44
Description: Homo sapiens TCDD inducible poly(ADP-ribose) polymerase (TIPARP), transcript variant 2, mRNA. (from RefSeq NM_015508) RefSeq Summary (NM_015508): This gene encodes a member of the poly(ADP-ribose) polymerase superfamily. Studies of the mouse ortholog have shown that the encoded protein catalyzes histone poly(ADP-ribosyl)ation and may be involved in T-cell function. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]. Gencode Transcript: ENST00000295924.12 Gencode Gene: ENSG00000163659.13 Transcript (Including UTRs) Position: hg38 chr3:156,674,590-156,706,770 Size: 32,181 Total Exon Count: 6 Strand: + Coding Region Position: hg38 chr3:156,677,698-156,705,131 Size: 27,434 Coding Exon Count: 5
ID:PARPT_HUMAN DESCRIPTION: RecName: Full=TCDD-inducible poly [ADP-ribose] polymerase; EC=2.4.2.30; AltName: Full=ADP-ribosyltransferase diphtheria toxin-like 14; Short=ARTD14; AltName: Full=Poly [ADP-ribose] polymerase 7; Short=PARP-7; FUNCTION: Poly [ADP-ribose] polymerase using NAD(+) as a substrate to transfer ADP-ribose onto glutamic acid residues of a protein acceptor; repeated rounds of ADP-ribosylation leads to the formation of poly(ADPribose) chains on the protein, thereby altering the function of the target protein. May play a role in the adaptative response to chemical exposure (TCDD) and thereby mediates certain effects of the chemicals (By similarity). CATALYTIC ACTIVITY: NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor. SIMILARITY: Contains 1 C3H1-type zinc finger. SIMILARITY: Contains 1 PARP catalytic domain. SIMILARITY: Contains 1 WWE domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q7Z3E1
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0003950 NAD+ ADP-ribosyltransferase activity GO:0016740 transferase activity GO:0016757 transferase activity, transferring glycosyl groups GO:0035326 enhancer binding GO:0046872 metal ion binding
Biological Process: GO:0001570 vasculogenesis GO:0001822 kidney development GO:0006471 protein ADP-ribosylation GO:0006807 nitrogen compound metabolic process GO:0008209 androgen metabolic process GO:0008210 estrogen metabolic process GO:0008585 female gonad development GO:0009791 post-embryonic development GO:0010629 negative regulation of gene expression GO:0030097 hemopoiesis GO:0045732 positive regulation of protein catabolic process GO:0048008 platelet-derived growth factor receptor signaling pathway GO:0048705 skeletal system morphogenesis GO:0048745 smooth muscle tissue development GO:0060021 palate development GO:0060325 face morphogenesis GO:0071407 cellular response to organic cyclic compound