Human Gene TIPARP (ENST00000295924.12) from GENCODE V44
  Description: Homo sapiens TCDD inducible poly(ADP-ribose) polymerase (TIPARP), transcript variant 2, mRNA. (from RefSeq NM_015508)
RefSeq Summary (NM_015508): This gene encodes a member of the poly(ADP-ribose) polymerase superfamily. Studies of the mouse ortholog have shown that the encoded protein catalyzes histone poly(ADP-ribosyl)ation and may be involved in T-cell function. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010].
Gencode Transcript: ENST00000295924.12
Gencode Gene: ENSG00000163659.13
Transcript (Including UTRs)
   Position: hg38 chr3:156,674,590-156,706,770 Size: 32,181 Total Exon Count: 6 Strand: +
Coding Region
   Position: hg38 chr3:156,677,698-156,705,131 Size: 27,434 Coding Exon Count: 5 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr3:156,674,590-156,706,770)mRNA (may differ from genome)Protein (657 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
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HGNCHPRDLynxMGIneXtProtOMIM
PubMedUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: PARPT_HUMAN
DESCRIPTION: RecName: Full=TCDD-inducible poly [ADP-ribose] polymerase; EC=2.4.2.30; AltName: Full=ADP-ribosyltransferase diphtheria toxin-like 14; Short=ARTD14; AltName: Full=Poly [ADP-ribose] polymerase 7; Short=PARP-7;
FUNCTION: Poly [ADP-ribose] polymerase using NAD(+) as a substrate to transfer ADP-ribose onto glutamic acid residues of a protein acceptor; repeated rounds of ADP-ribosylation leads to the formation of poly(ADPribose) chains on the protein, thereby altering the function of the target protein. May play a role in the adaptative response to chemical exposure (TCDD) and thereby mediates certain effects of the chemicals (By similarity).
CATALYTIC ACTIVITY: NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.
SIMILARITY: Contains 1 C3H1-type zinc finger.
SIMILARITY: Contains 1 PARP catalytic domain.
SIMILARITY: Contains 1 WWE domain.

-  Primer design for this transcript
 

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Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: TIPARP
Diseases sorted by gene-association score: male reproductive organ cancer (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 21.34 RPKM in Fallopian Tube
Total median expression: 424.81 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -108.80248-0.439 Picture PostScript Text
3' UTR -399.101639-0.244 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR012317 - Poly(ADP-ribose)pol_cat_dom
IPR004170 - WWE-dom
IPR000571 - Znf_CCCH

Pfam Domains:
PF00644 - Poly(ADP-ribose) polymerase catalytic domain

ModBase Predicted Comparative 3D Structure on Q7Z3E1
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003950 NAD+ ADP-ribosyltransferase activity
GO:0016740 transferase activity
GO:0016757 transferase activity, transferring glycosyl groups
GO:0035326 enhancer binding
GO:0046872 metal ion binding

Biological Process:
GO:0001570 vasculogenesis
GO:0001822 kidney development
GO:0006471 protein ADP-ribosylation
GO:0006807 nitrogen compound metabolic process
GO:0008209 androgen metabolic process
GO:0008210 estrogen metabolic process
GO:0008585 female gonad development
GO:0009791 post-embryonic development
GO:0010629 negative regulation of gene expression
GO:0030097 hemopoiesis
GO:0045732 positive regulation of protein catabolic process
GO:0048008 platelet-derived growth factor receptor signaling pathway
GO:0048705 skeletal system morphogenesis
GO:0048745 smooth muscle tissue development
GO:0060021 palate development
GO:0060325 face morphogenesis
GO:0071407 cellular response to organic cyclic compound

Cellular Component:
GO:0005634 nucleus


-  Descriptions from all associated GenBank mRNAs
  AK291261 - Homo sapiens cDNA FLJ77540 complete cds, highly similar to Homo sapiens TCDD-inducible poly(ADP-ribose) polymerase (TIPARP), mRNA.
BX537965 - Homo sapiens mRNA; cDNA DKFZp686N0351 (from clone DKFZp686N0351); complete cds.
BC050350 - Homo sapiens TCDD-inducible poly(ADP-ribose) polymerase, mRNA (cDNA clone MGC:51185 IMAGE:5264807), complete cds.
CR749647 - Homo sapiens mRNA; cDNA DKFZp686P1838 (from clone DKFZp686P1838).
AK097785 - Homo sapiens cDNA FLJ40466 fis, clone TESTI2042302.
BC034397 - Homo sapiens TCDD-inducible poly(ADP-ribose) polymerase, mRNA (cDNA clone IMAGE:5171906), partial cds.
AB463307 - Synthetic construct DNA, clone: pF1KB8673, Homo sapiens TIPARP gene for TCDD-inducible poly(ADP-ribose) polymerase, without stop codon, in Flexi system.
AM393433 - Synthetic construct Homo sapiens clone IMAGE:100001862 for hypothetical protein (TIPARP gene).
JD243546 - Sequence 224570 from Patent EP1572962.
JD398057 - Sequence 379081 from Patent EP1572962.
JD439980 - Sequence 421004 from Patent EP1572962.
JD184070 - Sequence 165094 from Patent EP1572962.
JD306514 - Sequence 287538 from Patent EP1572962.
JD523893 - Sequence 504917 from Patent EP1572962.
JD319062 - Sequence 300086 from Patent EP1572962.
JD369065 - Sequence 350089 from Patent EP1572962.
DQ572793 - Homo sapiens piRNA piR-40905, complete sequence.
AL080156 - Homo sapiens mRNA; cDNA DKFZp434J214 (from clone DKFZp434J214).
JD307882 - Sequence 288906 from Patent EP1572962.
JD363118 - Sequence 344142 from Patent EP1572962.
JD313842 - Sequence 294866 from Patent EP1572962.
JD326732 - Sequence 307756 from Patent EP1572962.
JD326425 - Sequence 307449 from Patent EP1572962.
JD150161 - Sequence 131185 from Patent EP1572962.
JD390279 - Sequence 371303 from Patent EP1572962.
JD175335 - Sequence 156359 from Patent EP1572962.
JD221292 - Sequence 202316 from Patent EP1572962.
JD315988 - Sequence 297012 from Patent EP1572962.
JD428600 - Sequence 409624 from Patent EP1572962.
JD559417 - Sequence 540441 from Patent EP1572962.
JD407911 - Sequence 388935 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: D3DNK6, ENST00000295924.1, ENST00000295924.10, ENST00000295924.11, ENST00000295924.2, ENST00000295924.3, ENST00000295924.4, ENST00000295924.5, ENST00000295924.6, ENST00000295924.7, ENST00000295924.8, ENST00000295924.9, NM_015508, PARP7, PARPT_HUMAN, Q68CY9, Q7Z3E1, Q86VP4, Q9Y4P7, uc003fav.1, uc003fav.2, uc003fav.3, uc003fav.4, uc003fav.5
UCSC ID: ENST00000295924.12
RefSeq Accession: NM_015508
Protein: Q7Z3E1 (aka PARPT_HUMAN)
CCDS: CCDS3177.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.