Human Gene LAMP3 (uc003flh.4) Description and Page Index
Description: Homo sapiens lysosomal-associated membrane protein 3 (LAMP3), mRNA. RefSeq Summary (NM_014398): Dendritic cells (DCs) are the most potent antigen-presenting cells. Immature DCs efficiently capture antigens and differentiate into interdigitating dendritic cells (IDCs) in lymphoid tissues that induce primary T-cell responses (summary by de Saint-Vis et al., 1998 [PubMed 9768752]).[supplied by OMIM, Dec 2010]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC032940.2, AB013924.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2144333 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000265598.8/ ENSP00000265598.3 RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## Transcript (Including UTRs) Position: hg19 chr3:182,840,003-182,880,667 Size: 40,665 Total Exon Count: 6 Strand: - Coding Region Position: hg19 chr3:182,841,869-182,880,443 Size: 38,575 Coding Exon Count: 6
ID:LAMP3_HUMAN DESCRIPTION: RecName: Full=Lysosome-associated membrane glycoprotein 3; Short=LAMP-3; Short=Lysosomal-associated membrane protein 3; AltName: Full=DC-lysosome-associated membrane glycoprotein; Short=DC LAMP; AltName: Full=Protein TSC403; AltName: CD_antigen=CD208; Flags: Precursor; FUNCTION: Might change the lysosome function after the transfer of peptide-MHC class II molecules to the surface of dendritic cells. SUBCELLULAR LOCATION: Lysosome membrane; Single-pass type I membrane protein. TISSUE SPECIFICITY: Expressed in lymphoid organs and dendritic cells. Expressed in lung. Up-regulated in carcinomas of the esophagus, colon, rectum, ureter, stomach, breast, fallopian tube, thyroid and parotid tissues. SIMILARITY: Belongs to the LAMP family.
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): LAMP3 CDC HuGE Published Literature: LAMP3 Positive Disease Associations: Bipolar Disorder Related Studies:
Bipolar Disorder Paul R Burton et al. Nature 2007, Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls., Nature.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9UQV4
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Biological Process: GO:0002250 adaptive immune response GO:0002376 immune system process GO:0010506 regulation of autophagy GO:0010628 positive regulation of gene expression GO:0035455 response to interferon-alpha GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:1901799 negative regulation of proteasomal protein catabolic process GO:1903900 regulation of viral life cycle GO:0046718 viral entry into host cell