Human Gene SENP2 (ENST00000296257.10) from GENCODE V44
Description: Homo sapiens SUMO specific peptidase 2 (SENP2), mRNA. (from RefSeq NM_021627) RefSeq Summary (NM_021627): SUMO1 (UBL1; MIM 601912) is a small ubiquitin-like protein that can be covalently conjugated to other proteins. SENP2 is one of a group of enzymes that process newly synthesized SUMO1 into the conjugatable form and catalyze the deconjugation of SUMO1-containing species.[supplied by OMIM, Apr 2004]. Gencode Transcript: ENST00000296257.10 Gencode Gene: ENSG00000163904.13 Transcript (Including UTRs) Position: hg38 chr3:185,586,295-185,633,551 Size: 47,257 Total Exon Count: 17 Strand: + Coding Region Position: hg38 chr3:185,586,414-185,629,844 Size: 43,431 Coding Exon Count: 17
ID:SENP2_HUMAN DESCRIPTION: RecName: Full=Sentrin-specific protease 2; EC=3.4.22.68; AltName: Full=Axam2; AltName: Full=SMT3-specific isopeptidase 2; Short=Smt3ip2; AltName: Full=Sentrin/SUMO-specific protease SENP2; FUNCTION: Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. May down-regulate CTNNB1 levels and thereby modulate the Wnt pathway (By similarity). CATALYTIC ACTIVITY: Hydrolysis of the alpha-linked peptide bond in the sequence Gly-Gly-|-Ala-Thr-Tyr at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptide, Smt3, leading to the mature form of the protein. A second reaction involves the cleavage of an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein. SUBUNIT: Binds to SUMO2 and SUMO3 (By similarity). Interacts with the C-terminal domain of NUP153 via its N-terminus. INTERACTION: Q9Y6K9:IKBKG; NbExp=3; IntAct=EBI-714881, EBI-81279; SUBCELLULAR LOCATION: Nucleus, nuclear pore complex. Nucleus membrane; Peripheral membrane protein; Nucleoplasmic side. Cytoplasm. Note=Shuttles between cytoplasm and nucleus. DOMAIN: The N-terminus is necessary and sufficient for nuclear envelope targeting. PTM: Polyubiquitinated; which leads to proteasomal degradation. SIMILARITY: Belongs to the peptidase C48 family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9HC62
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0001934 positive regulation of protein phosphorylation GO:0006508 proteolysis GO:0007507 heart development GO:0009950 dorsal/ventral axis specification GO:0015031 protein transport GO:0016055 Wnt signaling pathway GO:0016925 protein sumoylation GO:0016926 protein desumoylation GO:0030111 regulation of Wnt signaling pathway GO:0031397 negative regulation of protein ubiquitination GO:0031398 positive regulation of protein ubiquitination GO:0031648 protein destabilization GO:0032091 negative regulation of protein binding GO:0032875 regulation of DNA endoreduplication GO:0035562 negative regulation of chromatin binding GO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator GO:0045444 fat cell differentiation GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0051028 mRNA transport GO:0051246 regulation of protein metabolic process GO:0060707 trophoblast giant cell differentiation GO:0060711 labyrinthine layer development GO:0060712 spongiotrophoblast layer development GO:1901797 negative regulation of signal transduction by p53 class mediator GO:2000045 regulation of G1/S transition of mitotic cell cycle