Human Gene C4orf48 (ENST00000409860.1) from GENCODE V44
  Description: Homo sapiens chromosome 4 open reading frame 48 (C4orf48), transcript variant 2, mRNA. (from RefSeq NM_001141936)
Gencode Transcript: ENST00000409860.1
Gencode Gene: ENSG00000243449.8
Transcript (Including UTRs)
   Position: hg38 chr4:2,042,050-2,043,964 Size: 1,915 Total Exon Count: 4 Strand: +
Coding Region
   Position: hg38 chr4:2,042,352-2,043,926 Size: 1,575 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr4:2,042,050-2,043,964)mRNA (may differ from genome)Protein (95 aa)
Gene SorterGenome BrowserOther Species FASTATable SchemaAlphaFoldBioGPS
EnsemblEntrez GeneExonPrimerGencodeGeneCardsHGNC
LynxMalacardsMGIneXtProtOMIMPubMed
UniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: CD048_HUMAN
DESCRIPTION: RecName: Full=Neuropeptide-like protein C4orf48; Flags: Precursor;
SUBCELLULAR LOCATION: Secreted (Potential).
TISSUE SPECIFICITY: Brain-specific (at protein level).
MISCELLANEOUS: Share similarities with neuropeptides, however functional characterization is required to confirm this hypothesis (PubMed:21287218).
SEQUENCE CAUTION: Sequence=CAX14865.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 31.40 RPKM in Pituitary
Total median expression: 423.77 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -74.20151-0.491 Picture PostScript Text
3' UTR -9.5038-0.250 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  ModBase Predicted Comparative 3D Structure on Q5BLP8
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserGenome BrowserNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGDEnsembl   
Protein SequenceProtein SequenceProtein Sequence   
AlignmentAlignmentAlignment   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Cellular Component:
GO:0005576 extracellular region


-  Descriptions from all associated GenBank mRNAs
  BC062790 - Homo sapiens hypothetical gene supported by BC038466; BC062790, mRNA (cDNA clone IMAGE:4775221).
BC038466 - Homo sapiens hypothetical gene supported by BC038466; BC062790, mRNA (cDNA clone IMAGE:5226643).
BC047038 - Homo sapiens hypothetical gene supported by BC038466; BC062790, mRNA (cDNA clone IMAGE:5200861).
AY947524 - Homo sapiens CH455 mRNA, partial cds.

-  Other Names for This Gene
  Alternate Gene Symbols: B6ZDN0, B7ZBI7, B7ZBI8, CD048_HUMAN, Chr4_55, NM_001141936, Q5BLP8, uc003gep.1, uc003gep.2, uc003gep.3, uc003gep.4
UCSC ID: ENST00000409860.1
RefSeq Accession: NM_001141936
Protein: Q5BLP8 (aka CD048_HUMAN)
CCDS: CCDS47000.2

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.