Human Gene TMEM128 (ENST00000254742.6) from GENCODE V44
  Description: Homo sapiens transmembrane protein 128 (TMEM128), transcript variant 3, mRNA. (from RefSeq NM_032927)
Gencode Transcript: ENST00000254742.6
Gencode Gene: ENSG00000132406.12
Transcript (Including UTRs)
   Position: hg38 chr4:4,235,542-4,248,212 Size: 12,671 Total Exon Count: 5 Strand: -
Coding Region
   Position: hg38 chr4:4,237,836-4,247,625 Size: 9,790 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr4:4,235,542-4,248,212)mRNA (may differ from genome)Protein (141 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards
HGNCHPRDLynxMalacardsMGIneXtProt
PubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: TM128_HUMAN
DESCRIPTION: RecName: Full=Transmembrane protein 128;
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Potential).

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 13.18 RPKM in Brain - Spinal cord (cervical c-1)
Total median expression: 452.09 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -215.00587-0.366 Picture PostScript Text
3' UTR -161.40724-0.223 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  ModBase Predicted Comparative 3D Structure on Q5BJH2
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003674 molecular_function
GO:0005515 protein binding

Biological Process:
GO:0008150 biological_process

Cellular Component:
GO:0005575 cellular_component
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  LF206822 - JP 2014500723-A/14325: Polycomb-Associated Non-Coding RNAs.
MA442399 - JP 2018138019-A/14325: Polycomb-Associated Non-Coding RNAs.
AK001453 - Homo sapiens cDNA FLJ10591 fis, clone NT2RP2004602.
BC007729 - Homo sapiens transmembrane protein 128, mRNA (cDNA clone MGC:13159 IMAGE:4303698), complete cds.
BC091482 - Homo sapiens transmembrane protein 128, mRNA (cDNA clone MGC:110944 IMAGE:30344390), complete cds.
CR933611 - Homo sapiens mRNA; cDNA DKFZp686N2443 (from clone DKFZp686N2443).
JD282232 - Sequence 263256 from Patent EP1572962.
JD182100 - Sequence 163124 from Patent EP1572962.
JD247474 - Sequence 228498 from Patent EP1572962.
JD363502 - Sequence 344526 from Patent EP1572962.
JD110717 - Sequence 91741 from Patent EP1572962.
JD503276 - Sequence 484300 from Patent EP1572962.
JD255671 - Sequence 236695 from Patent EP1572962.
JD308260 - Sequence 289284 from Patent EP1572962.
JD435512 - Sequence 416536 from Patent EP1572962.
JD270540 - Sequence 251564 from Patent EP1572962.
JD293519 - Sequence 274543 from Patent EP1572962.
JD293518 - Sequence 274542 from Patent EP1572962.
JD438315 - Sequence 419339 from Patent EP1572962.
JD043494 - Sequence 24518 from Patent EP1572962.
JD520183 - Sequence 501207 from Patent EP1572962.
AK296007 - Homo sapiens cDNA FLJ51973 complete cds.
AK295248 - Homo sapiens cDNA FLJ59889 complete cds.
KJ895074 - Synthetic construct Homo sapiens clone ccsbBroadEn_04468 TMEM128 gene, encodes complete protein.
JD032181 - Sequence 13205 from Patent EP1572962.
JD024744 - Sequence 5768 from Patent EP1572962.
AK054701 - Homo sapiens cDNA FLJ30139 fis, clone BRACE2000109.
JD239422 - Sequence 220446 from Patent EP1572962.
JD046867 - Sequence 27891 from Patent EP1572962.
JD093373 - Sequence 74397 from Patent EP1572962.
JD183594 - Sequence 164618 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: B4DHS7, D3DVS3, ENST00000254742.1, ENST00000254742.2, ENST00000254742.3, ENST00000254742.4, ENST00000254742.5, NM_032927, Q5BJH2, Q5H9U6, Q96I94, TM128_HUMAN, uc003ghq.1, uc003ghq.2
UCSC ID: ENST00000254742.6
RefSeq Accession: NM_032927
Protein: Q5BJH2 (aka TM128_HUMAN)
CCDS: CCDS3373.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.