Human Gene MRFAP1 (ENST00000320912.8) from GENCODE V44
Description: Found in a complex composed of MORF4L1, MRFAP1 and RB1. Interacts via its N-terminus with MORF4L1. Interacts with CSTB and MORF4L2. (from UniProt Q9Y605) RefSeq Summary (NM_001272053): This gene encodes an intracellular protein that interacts with members of the MORF4/MRG (mortality factor on chromosome 4/MORF4 related gene) family and the tumor suppressor Rb (retinoblastoma protein.) The protein may play a role in senescence, cell growth and immortalization. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]. Gencode Transcript: ENST00000320912.8 Gencode Gene: ENSG00000179010.16 Transcript (Including UTRs) Position: hg38 chr4:6,640,091-6,642,729 Size: 2,639 Total Exon Count: 3 Strand: + Coding Region Position: hg38 chr4:6,640,863-6,641,246 Size: 384 Coding Exon Count: 1
ID:MOFA1_HUMAN DESCRIPTION: RecName: Full=MORF4 family-associated protein 1; AltName: Full=Protein PGR1; AltName: Full=Protein associated with MRG of 14 kDa; SUBUNIT: Found in a complex composed of MORF4L1, MRFAP1 and RB1. Interacts via its N-terminus with MORF4L1. Interacts with CSTB and MORF4L2. SUBCELLULAR LOCATION: Nucleus. Cytoplasm, perinuclear region. Note=Colocalizes with MORF4L1 to cell nuclei. SIMILARITY: Belongs to the MORF4 family-associated protein family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
ModBase Predicted Comparative 3D Structure on Q9Y605
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
