Human Gene PI4K2B (ENST00000264864.8) from GENCODE V44
Description: Homo sapiens phosphatidylinositol 4-kinase type 2 beta (PI4K2B), transcript variant 2, non-coding RNA. (from RefSeq NR_144633) RefSeq Summary (NM_018323): This gene encodes a member of the type II PI4 kinase protein family. The encoded protein is primarily cytosolic and contributes to overall PI4-kinase activity along with other protein family members. This protein is involved in early T cell activation. [provided by RefSeq, Dec 2016]. Gencode Transcript: ENST00000264864.8 Gencode Gene: ENSG00000038210.14 Transcript (Including UTRs) Position: hg38 chr4:25,234,033-25,279,204 Size: 45,172 Total Exon Count: 10 Strand: + Coding Region Position: hg38 chr4:25,234,164-25,277,187 Size: 43,024 Coding Exon Count: 10
ID:P4K2B_HUMAN DESCRIPTION: RecName: Full=Phosphatidylinositol 4-kinase type 2-beta; EC=2.7.1.67; AltName: Full=Phosphatidylinositol 4-kinase type II-beta; Short=PI4KII-BETA; FUNCTION: Together with PI4K2A and the type III PI4Ks (PIK4CA and PIK4CB) it contributes to the overall PI4-kinase activity of the cell. This contribution may be especially significant in plasma membrane, endosomal and Golgi compartments. The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3). Contributes to the production of InsP3 in stimulated cells and is likely to be involved in the regulation of vesicular trafficking. CATALYTIC ACTIVITY: ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate. ENZYME REGULATION: Recruited and activated by membrane association. Binding to the microsomal membrane has been shown to enhance its activity. SUBCELLULAR LOCATION: Cytoplasm. Membrane. Note=Mostly cytoplasmic but also found associated with the plasma membrane, the Golgi and endosomes. Compared to PI4K2A, a larger fraction of PI4K2B is cytosolic due to a smaller extent of palmitoylation. Translocates to membranes where it is recruited by PDGF stimulation by a Rac- GTP-dependent mechanism. TISSUE SPECIFICITY: Widely expressed. SIMILARITY: Belongs to the PI3/PI4-kinase family. Type II PI4K subfamily. SIMILARITY: Contains 1 PI3K/PI4K domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00454 - Phosphatidylinositol 3- and 4-kinase
ModBase Predicted Comparative 3D Structure on Q8TCG2
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Protein Q8TCG2 (Reactome details) participates in the following event(s):
R-HSA-1675780 PI is phosphorylated to PI4P by PI4K2A/B at the plasma membrane R-HSA-1675974 PI is phosphorylated to PI4P by PI4K2A/B at the early endosome membrane R-HSA-1676185 PI is phosphorylated to PI4P by PI4KA/2A/2B at the Golgi membrane R-HSA-1675813 PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane R-HSA-1660499 Synthesis of PIPs at the plasma membrane R-HSA-1660516 Synthesis of PIPs at the early endosome membrane R-HSA-1660514 Synthesis of PIPs at the Golgi membrane R-HSA-1483248 Synthesis of PIPs at the ER membrane R-HSA-1483255 PI Metabolism R-HSA-1483257 Phospholipid metabolism R-HSA-556833 Metabolism of lipids R-HSA-1430728 Metabolism
US Server
