Human Gene SMIM20 (ENST00000506197.3) from GENCODE V44
  Description: Homo sapiens small integral membrane protein 20 (SMIM20), mRNA. (from RefSeq NM_001145432)
Gencode Transcript: ENST00000506197.3
Gencode Gene: ENSG00000250317.9
Transcript (Including UTRs)
   Position: hg38 chr4:25,914,220-25,929,812 Size: 15,593 Total Exon Count: 3 Strand: +
Coding Region
   Position: hg38 chr4:25,914,314-25,929,191 Size: 14,878 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA-Seq Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther Names
Methods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr4:25,914,220-25,929,812)mRNA (may differ from genome)Protein (67 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards
HGNCHPRDMalacardsMGIneXtProtOMIM
PubMedUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: CD052_HUMAN
DESCRIPTION: RecName: Full=Uncharacterized protein C4orf52;
SUBCELLULAR LOCATION: Membrane; Single-pass membrane protein (Potential).
SEQUENCE CAUTION: Sequence=AAH32431.1; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 17.81 RPKM in Adrenal Gland
Total median expression: 631.08 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -45.1094-0.480 Picture PostScript Text
3' UTR -157.60621-0.254 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  ModBase Predicted Comparative 3D Structure on Q8N5G0
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserNo orthologGenome BrowserNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGI Ensembl   
Protein Sequence Protein Sequence   
Alignment Alignment   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding

Biological Process:
GO:0033617 mitochondrial respiratory chain complex IV assembly

Cellular Component:
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  BC032431 - Homo sapiens hypothetical protein LOC389203, mRNA (cDNA clone IMAGE:4521185), partial cds.
BC086307 - Homo sapiens hypothetical gene supported by BC032431, mRNA (cDNA clone IMAGE:4855921).
BC006003 - Homo sapiens hypothetical protein LOC389203, mRNA (cDNA clone IMAGE:4247529), partial cds.
BC046171 - Homo sapiens hypothetical gene supported by BC032431, mRNA (cDNA clone IMAGE:3453987).
BC062747 - Homo sapiens hypothetical gene supported by BC032431, mRNA (cDNA clone IMAGE:6454026).
BC014348 - Homo sapiens hypothetical protein LOC389203, mRNA (cDNA clone IMAGE:4052356), with apparent retained intron.
BC040154 - Homo sapiens hypothetical gene supported by BC032431, mRNA (cDNA clone IMAGE:3861979).

-  Other Names for This Gene
  Alternate Gene Symbols: C4orf52, C9JYT8, CD052_HUMAN, ENST00000506197.1, ENST00000506197.2, NM_001145432, Q8N5G0, Q9BRT5, uc003grw.1, uc003grw.2, uc003grw.3, uc003grw.4, uc003grw.5, uc003grw.6
UCSC ID: ENST00000506197.3
RefSeq Accession: NM_001145432
Protein: Q8N5G0 (aka CD052_HUMAN)

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.