Human Gene SMIM14 (ENST00000295958.10) from GENCODE V44
  Description: Homo sapiens small integral membrane protein 14 (SMIM14), transcript variant 2, mRNA. (from RefSeq NM_174921)
Gencode Transcript: ENST00000295958.10
Gencode Gene: ENSG00000163683.12
Transcript (Including UTRs)
   Position: hg38 chr4:39,546,336-39,638,865 Size: 92,530 Total Exon Count: 5 Strand: -
Coding Region
   Position: hg38 chr4:39,552,126-39,605,145 Size: 53,020 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr4:39,546,336-39,638,865)mRNA (may differ from genome)Protein (99 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards
HGNCHPRDLynxMalacardsMGIneXtProt
PubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: CD034_HUMAN
DESCRIPTION: RecName: Full=Uncharacterized protein C4orf34;
SUBCELLULAR LOCATION: Membrane; Single-pass membrane protein (Potential).

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 28.84 RPKM in Adrenal Gland
Total median expression: 505.79 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -55.50162-0.343 Picture PostScript Text
3' UTR -1787.405790-0.309 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR020309 - Uncharacterised_CD034/YQF4

Pfam Domains:
PF11027 - Protein of unknown function (DUF2615)

ModBase Predicted Comparative 3D Structure on Q96QK8
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserGenome BrowserGenome BrowserNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGDEnsemblEnsembl  
Protein SequenceProtein SequenceProtein SequenceProtein Sequence  
AlignmentAlignmentAlignmentAlignment  

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding

Cellular Component:
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  BC008502 - Homo sapiens chromosome 4 open reading frame 34, mRNA (cDNA clone MGC:14841 IMAGE:4295121), complete cds.
AK023351 - Homo sapiens cDNA FLJ13289 fis, clone OVARC1001170.
AK307146 - Homo sapiens cDNA, FLJ97094.
HQ447886 - Synthetic construct Homo sapiens clone IMAGE:100071238; CCSB005691_03 chromosome 4 open reading frame 34 (C4orf34) gene, encodes complete protein.
KJ895806 - Synthetic construct Homo sapiens clone ccsbBroadEn_05200 C4orf34 gene, encodes complete protein.
AK130274 - Homo sapiens cDNA FLJ26764 fis, clone PRS02668.
JD401502 - Sequence 382526 from Patent EP1572962.
JD401503 - Sequence 382527 from Patent EP1572962.
JD307016 - Sequence 288040 from Patent EP1572962.
JD170151 - Sequence 151175 from Patent EP1572962.
JD113340 - Sequence 94364 from Patent EP1572962.
JD383713 - Sequence 364737 from Patent EP1572962.
JD517175 - Sequence 498199 from Patent EP1572962.
JD104951 - Sequence 85975 from Patent EP1572962.
JD451571 - Sequence 432595 from Patent EP1572962.
JD139809 - Sequence 120833 from Patent EP1572962.
JD522754 - Sequence 503778 from Patent EP1572962.
JD448195 - Sequence 429219 from Patent EP1572962.
JD332231 - Sequence 313255 from Patent EP1572962.
JD471762 - Sequence 452786 from Patent EP1572962.
JD514875 - Sequence 495899 from Patent EP1572962.
JD179258 - Sequence 160282 from Patent EP1572962.
JD047559 - Sequence 28583 from Patent EP1572962.
JD490001 - Sequence 471025 from Patent EP1572962.
JD302861 - Sequence 283885 from Patent EP1572962.
JD503470 - Sequence 484494 from Patent EP1572962.
JD350199 - Sequence 331223 from Patent EP1572962.
JD350795 - Sequence 331819 from Patent EP1572962.
JD093288 - Sequence 74312 from Patent EP1572962.
JD069237 - Sequence 50261 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: C4orf34, CD034_HUMAN, ENST00000295958.1, ENST00000295958.2, ENST00000295958.3, ENST00000295958.4, ENST00000295958.5, ENST00000295958.6, ENST00000295958.7, ENST00000295958.8, ENST00000295958.9, NM_174921, Q96QK8, uc003guo.1, uc003guo.2, uc003guo.3, uc003guo.4, uc003guo.5
UCSC ID: ENST00000295958.10
RefSeq Accession: NM_174921
Protein: Q96QK8 (aka CD034_HUMAN)
CCDS: CCDS3456.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.