Human Gene PARM1 (ENST00000307428.7) from GENCODE V44
  Description: Homo sapiens prostate androgen-regulated mucin-like protein 1 (PARM1), mRNA. (from RefSeq NM_015393)
Gencode Transcript: ENST00000307428.7
Gencode Gene: ENSG00000169116.11
Transcript (Including UTRs)
   Position: hg38 chr4:74,933,116-75,050,113 Size: 116,998 Total Exon Count: 4 Strand: +
Coding Region
   Position: hg38 chr4:74,933,328-75,046,247 Size: 112,920 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr4:74,933,116-75,050,113)mRNA (may differ from genome)Protein (310 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards
HGNCHPRDLynxMGIneXtProtOMIM
PubMedUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: PARM1_HUMAN
DESCRIPTION: RecName: Full=Prostate androgen-regulated mucin-like protein 1; Short=PARM-1; Flags: Precursor;
FUNCTION: May regulate TLP1 expression and telomerase activity, thus enabling certain prostatic cells to resist apoptosis (By similarity).
SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein.
TISSUE SPECIFICITY: Widely expressed with highest levels in heart, kidney and placenta.
INDUCTION: By androgens.
PTM: Highly N-glycosylated and O-glycosylated.
SIMILARITY: Belongs to the PARM family.
SEQUENCE CAUTION: Sequence=CAB45720.1; Type=Frameshift; Positions=239;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: PARM1
Diseases sorted by gene-association score: bladder exstrophy-epispadias-cloacal exstrophy complex (11), exstrophy of bladder (8), epispadias (7)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 85.85 RPKM in Thyroid
Total median expression: 906.38 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -86.10212-0.406 Picture PostScript Text
3' UTR -1132.503866-0.293 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  ModBase Predicted Comparative 3D Structure on Q6UWI2
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserGenome BrowserNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGDEnsembl   
Protein SequenceProtein SequenceProtein Sequence   
AlignmentAlignmentAlignment   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Biological Process:
GO:0051973 positive regulation of telomerase activity

Cellular Component:
GO:0000139 Golgi membrane
GO:0005634 nucleus
GO:0005768 endosome
GO:0005769 early endosome
GO:0005770 late endosome
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0010008 endosome membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0043231 intracellular membrane-bounded organelle


-  Descriptions from all associated GenBank mRNAs
  AK022311 - Homo sapiens cDNA FLJ12249 fis, clone MAMMA1001411, highly similar to Protein PARM-1 precursor.
AY358777 - Homo sapiens clone DNA92223 VYKT1879 (UNQ1879) mRNA, complete cds.
BC013294 - Homo sapiens DKFZP564O0823 protein, mRNA (cDNA clone MGC:3551 IMAGE:3028327), complete cds.
AL080121 - Homo sapiens mRNA; cDNA DKFZp564O0823 (from clone DKFZp564O0823).
AM393174 - Synthetic construct Homo sapiens clone IMAGE:100001746 for hypothetical protein (DKFZP564O0823 gene).
AM393589 - Synthetic construct Homo sapiens clone IMAGE:100001752 for hypothetical protein (DKFZP564O0823 gene).
AB528828 - Synthetic construct DNA, clone: pF1KE0437, Homo sapiens UNQ1879/PRO4322 gene for Protein PARM-1, without stop codon, in Flexi system.
CU680556 - Synthetic construct Homo sapiens gateway clone IMAGE:100023319 5' read DKFZP564O0823 mRNA.
KJ898558 - Synthetic construct Homo sapiens clone ccsbBroadEn_07952 PARM1 gene, encodes complete protein.
JD462030 - Sequence 443054 from Patent EP1572962.
JD107692 - Sequence 88716 from Patent EP1572962.
JD166831 - Sequence 147855 from Patent EP1572962.
JD079301 - Sequence 60325 from Patent EP1572962.
JD459334 - Sequence 440358 from Patent EP1572962.
JD243973 - Sequence 224997 from Patent EP1572962.
JD299053 - Sequence 280077 from Patent EP1572962.
JD562446 - Sequence 543470 from Patent EP1572962.
JD551257 - Sequence 532281 from Patent EP1572962.
JD132741 - Sequence 113765 from Patent EP1572962.
JD150639 - Sequence 131663 from Patent EP1572962.
JD199032 - Sequence 180056 from Patent EP1572962.
JD312353 - Sequence 293377 from Patent EP1572962.
JD103179 - Sequence 84203 from Patent EP1572962.
JD320423 - Sequence 301447 from Patent EP1572962.
JD048705 - Sequence 29729 from Patent EP1572962.
JD078236 - Sequence 59260 from Patent EP1572962.
JD073995 - Sequence 55019 from Patent EP1572962.
JD541023 - Sequence 522047 from Patent EP1572962.
JD473044 - Sequence 454068 from Patent EP1572962.
JD515968 - Sequence 496992 from Patent EP1572962.
JD390306 - Sequence 371330 from Patent EP1572962.
JD126419 - Sequence 107443 from Patent EP1572962.
JD525486 - Sequence 506510 from Patent EP1572962.
JD518456 - Sequence 499480 from Patent EP1572962.
JD136611 - Sequence 117635 from Patent EP1572962.
JD088145 - Sequence 69169 from Patent EP1572962.
JD224591 - Sequence 205615 from Patent EP1572962.
JD447502 - Sequence 428526 from Patent EP1572962.
JD311446 - Sequence 292470 from Patent EP1572962.
JD563725 - Sequence 544749 from Patent EP1572962.
JD121267 - Sequence 102291 from Patent EP1572962.
AK025205 - Homo sapiens cDNA: FLJ21552 fis, clone COL06322.
AK026200 - Homo sapiens cDNA: FLJ22547 fis, clone HSI00356.

-  Other Names for This Gene
  Alternate Gene Symbols: B3KMQ9, ENST00000307428.1, ENST00000307428.2, ENST00000307428.3, ENST00000307428.4, ENST00000307428.5, ENST00000307428.6, NM_015393, PARM1_HUMAN, Q6UWI2, Q96DV8, Q9Y4S1, uc003hih.1, uc003hih.2, uc003hih.3, UNQ1879/PRO4322
UCSC ID: ENST00000307428.7
RefSeq Accession: NM_015393
Protein: Q6UWI2 (aka PARM1_HUMAN)
CCDS: CCDS47077.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.