Human Gene SLC39A8 (ENST00000394833.6) from GENCODE V44
Description: Homo sapiens solute carrier family 39 member 8 (SLC39A8), transcript variant 1, mRNA. (from RefSeq NM_022154) RefSeq Summary (NM_022154): This gene encodes a member of the SLC39 family of solute-carrier genes, which show structural characteristics of zinc transporters. The encoded protein is glycosylated and found in the plasma membrane and mitochondria, and functions in the cellular import of zinc at the onset of inflammation. It is also thought to be the primary transporter of the toxic cation cadmium, which is found in cigarette smoke. Multiple transcript variants encoding different isoforms have been found for this gene. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Oct 2008]. Gencode Transcript: ENST00000394833.6 Gencode Gene: ENSG00000138821.14 Transcript (Including UTRs) Position: hg38 chr4:102,261,666-102,345,139 Size: 83,474 Total Exon Count: 8 Strand: - Coding Region Position: hg38 chr4:102,263,044-102,344,662 Size: 81,619 Coding Exon Count: 8
ID:S39A8_HUMAN DESCRIPTION: RecName: Full=Zinc transporter ZIP8; AltName: Full=BCG-induced integral membrane protein in monocyte clone 103 protein; AltName: Full=LIV-1 subfamily of ZIP zinc transporter 6; Short=LZT-Hs6; AltName: Full=Solute carrier family 39 member 8; AltName: Full=Zrt- and Irt-like protein 8; Short=ZIP-8; FUNCTION: Acts as a zinc-influx transporter. SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Potential). Note=Associated with the lysosomal/endosomal compartment following transfection. TISSUE SPECIFICITY: Expressed in thymus, placenta, lung, liver, pancreas and, to a lower extent, in spleen, testis, ovary, small intestine, colon, leukocyte, heart. Highest expression is observed in pancreas. INDUCTION: By live and heat-killed Mycobacterium bovis bacterial cell wall and inflammatory cytokines like TNF. Down-regulated following phorbol ester treatment. SIMILARITY: Belongs to the ZIP transporter (TC 2.A.5) family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9C0K1
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AK304274 - Homo sapiens cDNA FLJ61547 complete cds, highly similar to Homo sapiens solute carrier family 39 (zinc transporter), member 8 (SLC39A8), mRNA. BC001320 - Homo sapiens solute carrier family 39 (zinc transporter), member 8, mRNA (cDNA clone IMAGE:3456026), partial cds. AB040120 - Homo sapiens mRNA for BCG induced integral membrane protein BIGM103, complete cds. AL049963 - Homo sapiens mRNA; cDNA DKFZp564A132 (from clone DKFZp564A132). BC012125 - Homo sapiens solute carrier family 39 (zinc transporter), member 8, mRNA (cDNA clone MGC:20193 IMAGE:4650026), complete cds. AK027652 - Homo sapiens cDNA FLJ14746 fis, clone NT2RP3002810, weakly similar to HISTIDINE-RICH PROTEIN KE4. JD350584 - Sequence 331608 from Patent EP1572962. JD297287 - Sequence 278311 from Patent EP1572962. JD303134 - Sequence 284158 from Patent EP1572962. JD335052 - Sequence 316076 from Patent EP1572962. JD091256 - Sequence 72280 from Patent EP1572962. AB020969 - Homo sapiens mRNA, 3'UTR, up-regulated by BCG-CWS. JD025243 - Sequence 6267 from Patent EP1572962. JD033230 - Sequence 14254 from Patent EP1572962. JD512364 - Sequence 493388 from Patent EP1572962. JD348112 - Sequence 329136 from Patent EP1572962. JD298256 - Sequence 279280 from Patent EP1572962. AB020970 - Homo sapiens mRNA, partial cds and 3'UTR, up-regulated by BCG-CWS. JD441335 - Sequence 422359 from Patent EP1572962. JD060958 - Sequence 41982 from Patent EP1572962. AF193052 - Homo sapiens PP3105 mRNA, complete cds. JD092639 - Sequence 73663 from Patent EP1572962. DQ892212 - Synthetic construct clone IMAGE:100004842; FLH184103.01X; RZPDo839C03144D solute carrier family 39 (zinc transporter), member 8 (SLC39A8) gene, encodes complete protein. KJ894532 - Synthetic construct Homo sapiens clone ccsbBroadEn_03926 SLC39A8 gene, encodes complete protein. DQ895407 - Synthetic construct Homo sapiens clone IMAGE:100009867; FLH184099.01L; RZPDo839C03143D solute carrier family 39 (zinc transporter), member 8 (SLC39A8) gene, encodes complete protein. CU680230 - Synthetic construct Homo sapiens gateway clone IMAGE:100019504 5' read SLC39A8 mRNA. JD381367 - Sequence 362391 from Patent EP1572962. JD146881 - Sequence 127905 from Patent EP1572962. JD520373 - Sequence 501397 from Patent EP1572962. JD395969 - Sequence 376993 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q9C0K1 (Reactome details) participates in the following event(s):
R-HSA-442387 ZIP8 mediates zinc influx into cells R-HSA-442380 Zinc influx into cells by the SLC39 gene family R-HSA-435354 Zinc transporters R-HSA-425410 Metal ion SLC transporters R-HSA-425366 Transport of bile salts and organic acids, metal ions and amine compounds R-HSA-425407 SLC-mediated transmembrane transport R-HSA-382551 Transport of small molecules
US Server
