Human Gene TRIM2 (ENST00000338700.10) Description and Page Index
Description: Homo sapiens tripartite motif containing 2 (TRIM2), transcript variant 1, mRNA. (from RefSeq NM_015271) RefSeq Summary (NM_015271): The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic filaments. It plays a neuroprotective role and functions as an E3-ubiquitin ligase in proteasome-mediated degradation of target proteins. Mutations in this gene can cause early-onset axonal neuropathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]. Gencode Transcript: ENST00000338700.10 Gencode Gene: ENSG00000109654.15 Transcript (Including UTRs) Position: hg38 chr4:153,204,443-153,339,317 Size: 134,875 Total Exon Count: 12 Strand: + Coding Region Position: hg38 chr4:153,204,531-153,334,966 Size: 130,436 Coding Exon Count: 12
ID:TRIM2_HUMAN DESCRIPTION: RecName: Full=Tripartite motif-containing protein 2; EC=6.3.2.-; AltName: Full=E3 ubiquitin-protein ligase TRIM2; AltName: Full=RING finger protein 86; FUNCTION: UBE2D1-dependent E3 ubiquitin-protein ligase that mediates the ubiquitination of NEFL and of phosphorylated BCL2L11 (By similarity). Plays a neuroprotective function (By similarity). May play a role in neuronal rapid ischemic tolerance (By similarity). PATHWAY: Protein modification; protein ubiquitination. SUBUNIT: Interacts with myosin V; myosin V may not be a substrate for ubiquitination (By similarity). Interacts with NEFL (By similarity). Interacts with phosphorylated BCL2L11. SUBCELLULAR LOCATION: Cytoplasm (By similarity). DOMAIN: The interaction with myosin V is dependent upon its NHL repeats, which form a beta-propeller (NHL) domain containing six blades (By similarity). PTM: RING-type zinc finger-dependent and UBE2D1-dependent autoubiquitination (By similarity). SIMILARITY: Belongs to the TRIM/RBCC family. SIMILARITY: Contains 1 B box-type zinc finger. SIMILARITY: Contains 1 filamin repeat. SIMILARITY: Contains 6 NHL repeats. SIMILARITY: Contains 1 RING-type zinc finger. SEQUENCE CAUTION: Sequence=BAA25443.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9C040
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.