Human Gene TRIM61 (ENST00000329314.6) from GENCODE V44
  Description: Homo sapiens tripartite motif containing 61 (TRIM61), mRNA. (from RefSeq NM_001012414)
Gencode Transcript: ENST00000329314.6
Gencode Gene: ENSG00000183439.10
Transcript (Including UTRs)
   Position: hg38 chr4:164,954,446-164,977,657 Size: 23,212 Total Exon Count: 5 Strand: -
Coding Region
   Position: hg38 chr4:164,954,992-164,970,002 Size: 15,011 Coding Exon Count: 2 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr4:164,954,446-164,977,657)mRNA (may differ from genome)Protein (209 aa)
Gene SorterGenome BrowserOther Species FASTATable SchemaAlphaFoldBioGPS
EnsemblEntrez GeneExonPrimerGencodeGeneCardsHGNC
HPRDLynxMalacardsMGIneXtProtPubMed
UniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: TRI61_HUMAN
DESCRIPTION: RecName: Full=Putative tripartite motif-containing protein 61; AltName: Full=RING finger protein 35;
SIMILARITY: Contains 1 B box-type zinc finger.
SIMILARITY: Contains 1 RING-type zinc finger.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 5.39 RPKM in Testis
Total median expression: 24.00 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -201.10602-0.334 Picture PostScript Text
3' UTR -76.20339-0.225 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000315 - Znf_B-box
IPR018957 - Znf_C3HC4_RING-type
IPR001841 - Znf_RING
IPR013083 - Znf_RING/FYVE/PHD
IPR017907 - Znf_RING_CS

Pfam Domains:
PF00643 - B-box zinc finger
PF00097 - Zinc finger, C3HC4 type (RING finger)

ModBase Predicted Comparative 3D Structure on Q5EBN2
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0008270 zinc ion binding
GO:0046872 metal ion binding

Cellular Component:
GO:0005622 intracellular


-  Descriptions from all associated GenBank mRNAs
  BC089393 - Homo sapiens tripartite motif-containing 61, mRNA (cDNA clone MGC:102996 IMAGE:30378540), complete cds.
KJ896229 - Synthetic construct Homo sapiens clone ccsbBroadEn_05623 TRIM61 gene, encodes complete protein.
AK296100 - Homo sapiens cDNA FLJ60274 complete cds, moderately similar to Homo sapiens tripartite motif-containing 60 (TRIM60), mRNA.
JD349562 - Sequence 330586 from Patent EP1572962.
JD022133 - Sequence 3157 from Patent EP1572962.
JD034130 - Sequence 15154 from Patent EP1572962.
JD495121 - Sequence 476145 from Patent EP1572962.
JD261962 - Sequence 242986 from Patent EP1572962.
JD086990 - Sequence 68014 from Patent EP1572962.
JD554977 - Sequence 536001 from Patent EP1572962.
JD059429 - Sequence 40453 from Patent EP1572962.
JD458883 - Sequence 439907 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000329314.1, ENST00000329314.2, ENST00000329314.3, ENST00000329314.4, ENST00000329314.5, NM_001012414, Q5EBN2, RNF35, TRI61_HUMAN, uc003iqw.1, uc003iqw.2, uc003iqw.3, uc003iqw.4, uc003iqw.5
UCSC ID: ENST00000329314.6
RefSeq Accession: NM_001012414
Protein: Q5EBN2 (aka TRI61_HUMAN)
CCDS: CCDS34093.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.