Human Gene NEIL3 (ENST00000264596.4) from GENCODE V44
Description: Homo sapiens nei like DNA glycosylase 3 (NEIL3), mRNA. (from RefSeq NM_018248) RefSeq Summary (NM_018248): NEIL3 belongs to a class of DNA glycosylases homologous to the bacterial Fpg/Nei family. These glycosylases initiate the first step in base excision repair by cleaving bases damaged by reactive oxygen species and introducing a DNA strand break via the associated lyase reaction (Bandaru et al., 2002 [PubMed 12509226]).[supplied by OMIM, Mar 2008]. Gencode Transcript: ENST00000264596.4 Gencode Gene: ENSG00000109674.4 Transcript (Including UTRs) Position: hg38 chr4:177,309,874-177,362,936 Size: 53,063 Total Exon Count: 10 Strand: + Coding Region Position: hg38 chr4:177,309,954-177,362,471 Size: 52,518 Coding Exon Count: 10
ID:NEIL3_HUMAN DESCRIPTION: RecName: Full=Endonuclease 8-like 3; EC=3.2.2.-; EC=4.2.99.18; AltName: Full=DNA glycosylase FPG2; AltName: Full=DNA glycosylase/AP lyase Neil3; AltName: Full=Endonuclease VIII-like 3; AltName: Full=Nei-like protein 3; FUNCTION: Reports about DNA glycosylase activity are contradictory. A number of references report finding no DNA glycosylase activity and the protein lacks a proline residue at the N-terminus which functions as an active site residue in other members of the FPG family. However, the mouse ortholog has been shown to have both DNA glycosylase and AP lyase activities and PubMed:19170771 demonstrates AP lyase activity. Prefers single- stranded DNA or partially single-stranded DNA structures such as bubble and fork structures to double-stranded DNA in vitro. Displays a broad recognition spectrum, preferring FapyA and FapyG followed by 5-OHU, 5-PHC and 5-OHMH and then Tg and 8-oxoA. No activity on 8-oxoG detected. CATALYTIC ACTIVITY: Removes damaged bases from DNA, leaving an abasic site. CATALYTIC ACTIVITY: The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate. SUBCELLULAR LOCATION: Nucleus. TISSUE SPECIFICITY: Detected in thymus and testis. Expressed at higher levels in tumor tissue than in the corresponding normal tissues except for pancreas and testis where expression is higher in normal than tumor tissue. SIMILARITY: Belongs to the FPG family. SIMILARITY: Contains 1 FPG-type zinc finger. SIMILARITY: Contains 1 RanBP2-type zinc finger. WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/neil3/";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF06831 - Formamidopyrimidine-DNA glycosylase H2TH domain PF06839 - GRF zinc finger PF00641 - Zn-finger in Ran binding protein and others
ModBase Predicted Comparative 3D Structure on Q8TAT5
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
