Human Gene ROPN1L (ENST00000274134.5) from GENCODE V44
  Description: Homo sapiens rhophilin associated tail protein 1 like (ROPN1L), transcript variant 1, mRNA. (from RefSeq NM_031916)
RefSeq Summary (NM_031916): This gene encodes a member of the ropporin family. The encoded protein is present in sperm and interacts with A-kinase anchoring protein, AKAP3, through the amphipathic helix region of AKAP3. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2014].
Gencode Transcript: ENST00000274134.5
Gencode Gene: ENSG00000145491.12
Transcript (Including UTRs)
   Position: hg38 chr5:10,441,879-10,465,026 Size: 23,148 Total Exon Count: 5 Strand: +
Coding Region
   Position: hg38 chr5:10,442,168-10,464,947 Size: 22,780 Coding Exon Count: 5 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr5:10,441,879-10,465,026)mRNA (may differ from genome)Protein (230 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards
HGNCHPRDLynxMalacardsMGIneXtProt
OMIMPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: ROP1L_HUMAN
DESCRIPTION: RecName: Full=Ropporin-1-like protein; Short=ROPN1-like protein; AltName: Full=AKAP-associated sperm protein;
SUBUNIT: May interact with AKAP3.
SIMILARITY: Belongs to the ropporin family.
SIMILARITY: Contains 1 RIIa domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: ROPN1L
Diseases sorted by gene-association score: opisthorchiasis (5)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 235.68 RPKM in Testis
Total median expression: 261.84 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -130.80289-0.453 Picture PostScript Text
3' UTR -8.2079-0.104 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR003117 - cAMP_dep_PK_reg_su_I/II_a/b

ModBase Predicted Comparative 3D Structure on Q96C74
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGDEnsembl   
Protein SequenceProtein SequenceProtein Sequence   
AlignmentAlignmentAlignment   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding

Biological Process:
GO:0001932 regulation of protein phosphorylation
GO:0003341 cilium movement
GO:0003351 epithelial cilium movement
GO:0030317 flagellated sperm motility
GO:0048240 sperm capacitation

Cellular Component:
GO:0005737 cytoplasm
GO:0005929 cilium
GO:0031514 motile cilium
GO:0042995 cell projection


-  Descriptions from all associated GenBank mRNAs
  LP895507 - Sequence 371 from Patent EP3253886.
BC014607 - Homo sapiens ropporin 1-like, mRNA (cDNA clone MGC:26950 IMAGE:4820798), complete cds.
JD308608 - Sequence 289632 from Patent EP1572962.
JD294940 - Sequence 275964 from Patent EP1572962.
AK098642 - Homo sapiens cDNA FLJ25776 fis, clone TST06548.
JD408267 - Sequence 389291 from Patent EP1572962.
JD404676 - Sequence 385700 from Patent EP1572962.
JD187419 - Sequence 168443 from Patent EP1572962.
AF239723 - Homo sapiens AKAP-associated sperm protein (ASP) mRNA, complete cds.
JF432599 - Synthetic construct Homo sapiens clone IMAGE:100073836 ropporin 1-like (ROPN1L) gene, encodes complete protein.
KJ899725 - Synthetic construct Homo sapiens clone ccsbBroadEn_09119 ROPN1L gene, encodes complete protein.
AK026656 - Homo sapiens cDNA: FLJ23003 fis, clone LNG00331.

-  Other Names for This Gene
  Alternate Gene Symbols: ASP, D3DTC9, ENST00000274134.1, ENST00000274134.2, ENST00000274134.3, ENST00000274134.4, NM_031916, Q96C74, Q9BZX0, ROP1L_HUMAN, uc003jex.1, uc003jex.2, uc003jex.3, uc003jex.4, uc003jex.5, uc003jex.6
UCSC ID: ENST00000274134.5
RefSeq Accession: NM_031916
Protein: Q96C74 (aka ROP1L_HUMAN)
CCDS: CCDS3879.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.