Human Gene DNAJC21 (ENST00000382021.2) from GENCODE V44
Description: Homo sapiens DnaJ heat shock protein family (Hsp40) member C21 (DNAJC21), transcript variant 1, mRNA. (from RefSeq NM_194283) RefSeq Summary (NM_194283): This gene encodes a member of the DNAJ heat shock protein 40 family of proteins that is characterized by two N-terminal tetratricopeptide repeat domains and a C-terminal DNAJ domain. This protein binds the precursor 45S ribosomal RNA and may be involved in early nuclear ribosomal RNA biogenesis and maturation of the 60S ribosomal subunit. Mutations in this gene result in Bone marrow failure syndrome 3. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2017]. Gencode Transcript: ENST00000382021.2 Gencode Gene: ENSG00000168724.18 Transcript (Including UTRs) Position: hg38 chr5:34,929,593-34,958,964 Size: 29,372 Total Exon Count: 13 Strand: + Coding Region Position: hg38 chr5:34,929,820-34,954,714 Size: 24,895 Coding Exon Count: 13
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q5F1R6
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
