Human Gene CCNO (ENST00000501463.2) from GENCODE V44
Description: Homo sapiens cyclin O (CCNO), transcript variant 2, non-coding RNA. (from RefSeq NR_125346) RefSeq Summary (NR_125346): This gene encodes a member of the cyclin protein family, and the encoded protein is involved in regulation of the cell cycle. Disruption of this gene is associated with primary ciliary dyskinesia-19. Alternative splicing results in multiple transcript variants. This gene, which has a previous symbol of UNG2, was erroneously identified as a uracil DNA glycosylase in PubMed ID: 2001396. A later publication, PubMed ID: 8419333, identified this gene's product as a cyclin protein family member. The UNG2 symbol is also used as a specific protein isoform name for the UNG gene (GeneID 7374), so confusion exists in the scientific literature and in some databases for these two genes. [provided by RefSeq, Jul 2014]. Gencode Transcript: ENST00000501463.2 Gencode Gene: ENSG00000152669.9 Transcript (Including UTRs) Position: hg38 chr5:55,231,152-55,233,597 Size: 2,446 Total Exon Count: 3 Strand: - Coding Region Position: hg38 chr5:55,233,128-55,233,523 Size: 396 Coding Exon Count: 1
ID:CCNO_HUMAN DESCRIPTION: RecName: Full=Cyclin-O; DEVELOPMENTAL STAGE: Maximum levels during G(1) phase. Levels decrease through S and G(2) phases. SIMILARITY: Belongs to the cyclin family. CAUTION: Was originally thought to have uracil-DNA glycosylase (UDG) activity and wrongly named UNG2 and UDG2 (PubMed:2001396). It was later shown that it is a member of the cyclin family (PubMed:8419333). UNG2 corresponds to the isoform 2 of UNG gene. SEQUENCE CAUTION: Sequence=AAB05817.1; Type=Miscellaneous discrepancy; Note=Sequencing errors; Sequence=CAA36728.1; Type=Miscellaneous discrepancy; Note=Sequencing errors;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P22674
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
