Human Gene BDP1 (ENST00000358731.9) from GENCODE V44
Description: Homo sapiens B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB (BDP1), mRNA. (from RefSeq NM_018429) RefSeq Summary (NM_018429): The product of this gene is a subunit of the TFIIIB transcription initiation complex, which recruits RNA polymerase III to target promoters in order to initiate transcription. The encoded protein localizes to concentrated aggregates in the nucleus, and is required for transcription from all three types of polymerase III promoters. It is phosphorylated by casein kinase II during mitosis, resulting in its release from chromatin and suppression of polymerase III transcription. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000358731.9 Gencode Gene: ENSG00000145734.20 Transcript (Including UTRs) Position: hg38 chr5:71,455,651-71,567,820 Size: 112,170 Total Exon Count: 39 Strand: + Coding Region Position: hg38 chr5:71,455,878-71,564,885 Size: 109,008 Coding Exon Count: 39
ID:BDP1_HUMAN DESCRIPTION: RecName: Full=Transcription factor TFIIIB component B'' homolog; AltName: Full=Transcription factor IIIB 150; Short=TFIIIB150; AltName: Full=Transcription factor-like nuclear regulator; FUNCTION: General activator of RNA polymerase III transcription. Requires for transcription from all three types of polymerase III promoters. Requires for transcription of genes with internal promoter elements and with promoter elements upstream of the initiation site. SUBUNIT: Component of TFIIIB complex. The TFIIIB complex has two activities, alpha and beta. The TFIIIB-alpha and TFIIIB-beta activities are required for transcription of genes with TFIIIC- bound internal promoters and PSE transcription factor-bound external promoters, respectively. The TFIIIB-alpha activity complex is composed of TBP, BDP1, and a complex containing both BRF2 and at least four stably associated proteins; YY1 facilitates the formation of TFIIIB-alpha activity complex. The TFIIIB-beta activity complex is composed of TBP, BDP1, and BRF1. Interacts with BRF1; this interaction diminishes during mitosis resulting in the release of BDP1 from chromosomal templates. Component of TFIIIC complex. The TFIIIC complex has two activities, C1 and C2. The TFIIIC2 activity complex is only required for transcription of the 'classical' pol III genes whereas the TFIIIC1 activity complex is required for transcription of all pol III genes. The TFIIIC1 activity complex is composed at least of BDP1. Interacts with ZBTB43. SUBCELLULAR LOCATION: Nucleus. TISSUE SPECIFICITY: Isoform 2 is highly expressed in cerebellum. INDUCTION: By Epstein-Barr virus (EBV) resulting in the stimulation of the EBV EBER genes. PTM: Phosphorylated by CSNK2A1 during mitosis, resulting in its release from chromatin and suppression of polymerase III transcription. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. SIMILARITY: Contains 1 Myb-like domain. SEQUENCE CAUTION: Sequence=AAG09268.1; Type=Frameshift; Positions=837, 863; Sequence=AAH32146.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence; Sequence=BAA86555.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=BAB21780.3; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=CAH18085.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on A6H8Y1
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006359 regulation of transcription from RNA polymerase III promoter GO:0006383 transcription from RNA polymerase III promoter GO:0070898 RNA polymerase III transcriptional preinitiation complex assembly
AB033067 - Homo sapiens mRNA for KIAA1241 protein, partial cds. AB051476 - Homo sapiens KIAA1689 mRNA for KIAA1689 protein. BC146792 - Homo sapiens B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB, mRNA (cDNA clone MGC:166890 IMAGE:9007260), complete cds. BC161615 - Homo sapiens B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB, mRNA (cDNA clone IMAGE:8860129), partial cds. CR749289 - Homo sapiens mRNA; cDNA DKFZp686L02246 (from clone DKFZp686L02246). CR749229 - Homo sapiens mRNA; cDNA DKFZp686K0831 (from clone DKFZp686K0831). BX641011 - Homo sapiens mRNA; cDNA DKFZp686C01233 (from clone DKFZp686C01233). AK057871 - Homo sapiens cDNA FLJ25142 fis, clone CBR07252, highly similar to Homo sapiens mRNA for putative transcription factor-like nuclear regulator (TFNR gene). AF176695 - Homo sapiens transcription factor IIIB 150 (TFIIIB150) mRNA, complete cds. BC032146 - Homo sapiens B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB, mRNA (cDNA clone IMAGE:5015560), partial cds. AJ238520 - Homo sapiens mRNA for putative transcription factor-like nuclear regulator (TFNR gene). JD407359 - Sequence 388383 from Patent EP1572962. JD462674 - Sequence 443698 from Patent EP1572962. JD462862 - Sequence 443886 from Patent EP1572962. JD065624 - Sequence 46648 from Patent EP1572962. JD232002 - Sequence 213026 from Patent EP1572962. JD217740 - Sequence 198764 from Patent EP1572962. AF298151 - Homo sapiens RNA polymerase III transcription initiation factor B'' mRNA, complete cds. AF298152 - Homo sapiens RNA polymerase III transcription initiation factor B'' short mRNA, complete cds. JD408402 - Sequence 389426 from Patent EP1572962. AB384624 - Synthetic construct DNA, clone: pF1KA1689, Homo sapiens BDP1 gene for B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB, complete cds, without stop codon, in Flexi system.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein A6H8Y1 (Reactome details) participates in the following event(s):
R-HSA-83723 Binding of TFIIIB to TFIIIC:TFIIIA:Type I Promoter complex R-HSA-83790 Binding of TFIIIB to TFIIC: Type 2 Promoter Complex R-HSA-83793 Binding of TFIIIB to SNAPc:Oct-1:Staf:Type 3 Promoter Complex R-HSA-76056 Recruitment of RNA polymerase III to TFIIIB:TFIIIC:TFIIIA:Type 1 Promoter Complex R-HSA-83805 Recruitment of RNA Polymerase III to the TFIIIB:TFIIIC: Type 2 Promoter Complex R-HSA-112055 RNA Polymerase III Abortive Initiation At Type 1 Open Promoters R-HSA-112153 RNA Polymerase III Simple Start Sequence Initiation At Type 1 Promoters R-HSA-76060 RNA Polymerase III Promoter Opening at Type 1 Promoters R-HSA-112149 RNA Polymerase III Abortive Initiation At Type 2 Open Promoters R-HSA-112155 RNA Polymerase III Simple Start Sequence Initiation At Type 2 Promoters R-HSA-112150 RNA Polymerase III Promoter Opening at Type 2 Promoters R-HSA-83803 Recruitment of RNA Polymerase III to TFIIIB:SNAPc:Type 3 Promoter Complex R-HSA-112054 RNA Polymerase III Abortive Initiation At Type 3 Open Promoters R-HSA-112156 RNA Polymerase III Simple Start Sequence Initiation At Type 3 Promoters R-HSA-112152 RNA Polymerase III Promoter Opening at Type 3 Promoters R-HSA-76061 RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76066 RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76071 RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-749476 RNA Polymerase III Abortive And Retractive Initiation R-HSA-76046 RNA Polymerase III Transcription Initiation R-HSA-74158 RNA Polymerase III Transcription R-HSA-74160 Gene expression (Transcription)
US Server
