Human Gene SSBP2 (ENST00000320672.9) from GENCODE V44
Description: Nucleus (By similarity). (from UniProt P81877) RefSeq Summary (NM_012446): This gene encodes a subunit of a protein complex that interacts with single-stranded DNA and is involved in the DNA damage response and maintenance of genome stability. The encoded protein may also play a role in telomere repair. A variant of this gene may be associated with survival in human glioblastoma patients. [provided by RefSeq, Sep 2016]. Gencode Transcript: ENST00000320672.9 Gencode Gene: ENSG00000145687.17 Transcript (Including UTRs) Position: hg38 chr5:81,412,804-81,751,097 Size: 338,294 Total Exon Count: 17 Strand: - Coding Region Position: hg38 chr5:81,420,504-81,751,042 Size: 330,539 Coding Exon Count: 17
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF04503 - Single-stranded DNA binding protein, SSDP
ModBase Predicted Comparative 3D Structure on P81877
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0003677 DNA binding GO:0003697 single-stranded DNA binding
Biological Process: GO:0006355 regulation of transcription, DNA-templated GO:0006366 transcription from RNA polymerase II promoter GO:0045944 positive regulation of transcription from RNA polymerase II promoter
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