Human Gene FAM81B (uc003kla.1) Description and Page Index
  Description: Homo sapiens family with sequence similarity 81, member B (FAM81B), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr5:94,727,048-94,786,144 Size: 59,097 Total Exon Count: 10 Strand: +
Coding Region
   Position: hg19 chr5:94,727,094-94,785,986 Size: 58,893 Coding Exon Count: 10 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr5:94,727,048-94,786,144)mRNA (may differ from genome)Protein (452 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsGeneNetwork
H-INVHGNCHPRDLynxMGIneXtProt
PubMedStanford SOURCETreefamUniProtKB

-  Comments and Description Text from UniProtKB
  ID: FA81B_HUMAN
DESCRIPTION: RecName: Full=Protein FAM81B;
SIMILARITY: Belongs to the FAM81 family.
CAUTION: It is uncertain whether Met-1 or Met-39 is the initiator. Met-1 does not seem to exist in orthologs.
SEQUENCE CAUTION: Sequence=AAH34772.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=BAB71646.1; Type=Frameshift; Positions=24;

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): FAM81B
CDC HuGE Published Literature: FAM81B
Positive Disease Associations: Hypertension
Related Studies:
  1. Hypertension
    , , . [PubMed 0]

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 42.11 RPKM in Testis
Total median expression: 49.91 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -9.0046-0.196 Picture PostScript Text
3' UTR -38.92158-0.246 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  ModBase Predicted Comparative 3D Structure on Q96LP2
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologGenome BrowserNo orthologNo orthologNo ortholog
      
      
  Ensembl   
  Protein Sequence   
  Alignment   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding

Cellular Component:
GO:0005634 nucleus


-  Descriptions from all associated GenBank mRNAs
  BC034772 - Homo sapiens family with sequence similarity 81, member B, mRNA (cDNA clone MGC:35162 IMAGE:5169904), complete cds.
AK058062 - Homo sapiens cDNA FLJ25333 fis, clone TST00656.
JF432157 - Synthetic construct Homo sapiens clone IMAGE:100073303 family with sequence similarity 81, member B (FAM81B) gene, encodes complete protein.
KJ903899 - Synthetic construct Homo sapiens clone ccsbBroadEn_13293 FAM81B gene, encodes complete protein.
AK310245 - Homo sapiens cDNA, FLJ17287.
CU689968 - Synthetic construct Homo sapiens gateway clone IMAGE:100019289 5' read FAM81B mRNA.
JD022837 - Sequence 3861 from Patent EP1572962.
JD035908 - Sequence 16932 from Patent EP1572962.
JD243612 - Sequence 224636 from Patent EP1572962.
JD541211 - Sequence 522235 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: FA81B_HUMAN, NM_152548, NP_689761, Q96LP2
UCSC ID: uc003kla.1
RefSeq Accession: NM_152548
Protein: Q96LP2 (aka FA81B_HUMAN)
CCDS: CCDS43341.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_152548.2
exon count: 10CDS single in 3' UTR: no RNA size: 1563
ORF size: 1359CDS single in intron: no Alignment % ID: 99.94
txCdsPredict score: 2489.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.