Human Gene RFESD (uc003klg.3) Description and Page Index
  Description: Homo sapiens Rieske (Fe-S) domain containing (RFESD), transcript variant 3, mRNA.
Transcript (Including UTRs)
   Position: hg19 chr5:94,982,481-94,992,849 Size: 10,369 Total Exon Count: 6 Strand: +
Coding Region
   Position: hg19 chr5:94,987,976-94,992,013 Size: 4,038 Coding Exon Count: 5 

Page IndexSequence and LinksCTDGene AllelesRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesmRNA DescriptionsOther NamesModel Information
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr5:94,982,481-94,992,849)mRNA (may differ from genome)Protein (210 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsGeneNetwork

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 2.61 RPKM in Testis
Total median expression: 12.63 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -40.80176-0.232 Picture PostScript Text
3' UTR -171.41836-0.205 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  Pfam Domains:
PF00355 - Rieske [2Fe-2S] domain
PF13806 - Rieske-like [2Fe-2S] domain

SCOP Domains:
50022 - ISP domain

ModBase Predicted Comparative 3D Structure on Q8TAC1-2
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     

-  Descriptions from all associated GenBank mRNAs
  BC048979 - Homo sapiens Rieske (Fe-S) domain containing, mRNA (cDNA clone MGC:57355 IMAGE:4838006), complete cds.
BC035110 - Homo sapiens Rieske (Fe-S) domain containing, mRNA (cDNA clone MGC:43188 IMAGE:5262922), complete cds.
BC024023 - Homo sapiens Rieske (Fe-S) domain containing, mRNA (cDNA clone MGC:27344 IMAGE:4670524), complete cds.
JD371384 - Sequence 352408 from Patent EP1572962.
KJ896027 - Synthetic construct Homo sapiens clone ccsbBroadEn_05421 RFESD gene, encodes complete protein.
JD328681 - Sequence 309705 from Patent EP1572962.
JD509409 - Sequence 490433 from Patent EP1572962.
JD041915 - Sequence 22939 from Patent EP1572962.
JD061440 - Sequence 42464 from Patent EP1572962.
JD284393 - Sequence 265417 from Patent EP1572962.
JD186568 - Sequence 167592 from Patent EP1572962.
JD170786 - Sequence 151810 from Patent EP1572962.
JD071628 - Sequence 52652 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: NM_001131066, NP_775498, Q8TAC1-2
UCSC ID: uc003klg.3
RefSeq Accession: NM_001131066
Protein: Q8TAC1-2, splice isoform of Q8TAC1 CCDS: CCDS47248.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_001131066.1
exon count: 6CDS single in 3' UTR: no RNA size: 1659
ORF size: 633CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 1199.50frame shift in genome: no % Coverage: 99.16
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.