Human Gene NUDT12 (ENST00000230792.7) from GENCODE V44
Description: Homo sapiens nudix hydrolase 12 (NUDT12), transcript variant 1, mRNA. (from RefSeq NM_031438) RefSeq Summary (NM_031438): Nucleotides are involved in numerous biochemical reactions and pathways within the cell as substrates, cofactors, and effectors. Nudix hydrolases, such as NUDT12, regulate the concentrations of individual nucleotides and of nucleotide ratios in response to changing circumstances (Abdelraheim et al., 2003 [PubMed 12790796]).[supplied by OMIM, Mar 2008]. Gencode Transcript: ENST00000230792.7 Gencode Gene: ENSG00000112874.10 Transcript (Including UTRs) Position: hg38 chr5:103,548,855-103,562,789 Size: 13,935 Total Exon Count: 7 Strand: - Coding Region Position: hg38 chr5:103,550,861-103,560,248 Size: 9,388 Coding Exon Count: 6
ID:NUD12_HUMAN DESCRIPTION: RecName: Full=Peroxisomal NADH pyrophosphatase NUDT12; EC=3.6.1.22; AltName: Full=Nucleoside diphosphate-linked moiety X motif 12; Short=Nudix motif 12; FUNCTION: Hydrolyzes NAD(P)H to NMNH and AMP (2',5'-ADP), and diadenosine diphosphate to AMP. Has also activity towards NAD(P)(+), ADP-ribose and diadenosine triphosphate. May act to regulate the concentration of peroxisomal nicotinamide nucleotide cofactors required for oxidative metabolism in this organelle. CATALYTIC ACTIVITY: NAD(+) + H(2)O = AMP + NMN. COFACTOR: Magnesium or manganese (By similarity). BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=11 uM for NADH; KM=16 uM for NADPH; KM=190 uM for NAD; pH dependence: Optimum pH is 8-9; SUBCELLULAR LOCATION: Peroxisome. SIMILARITY: Belongs to the Nudix hydrolase family. NudC subfamily. SIMILARITY: Contains 3 ANK repeats. SIMILARITY: Contains 1 nudix hydrolase domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9BQG2
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006742 NADP catabolic process GO:0019677 NAD catabolic process GO:0034356 NAD biosynthesis via nicotinamide riboside salvage pathway