Human Gene PRDM6 (ENST00000407847.5) from GENCODE V44
Description: Homo sapiens PR/SET domain 6 (PRDM6), mRNA. (from RefSeq NM_001136239) RefSeq Summary (NM_001136239): The protein encoded by this gene is a transcriptional repressor and a member of the PRDM family. Family members contain a PR domain and multiple zinc-finger domains. The encoded protein is involved in regulation of vascular smooth muscle cells (VSMC) contractile proteins. Mutations in this gene result in patent ductus arteriosus 3 (PDA3). [provided by RefSeq, Apr 2017]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Gencode Transcript: ENST00000407847.5 Gencode Gene: ENSG00000061455.11 Transcript (Including UTRs) Position: hg38 chr5:123,089,241-123,194,266 Size: 105,026 Total Exon Count: 8 Strand: + Coding Region Position: hg38 chr5:123,090,015-123,187,201 Size: 97,187 Coding Exon Count: 7
ID:PRDM6_HUMAN DESCRIPTION: RecName: Full=Putative histone-lysine N-methyltransferase PRDM6; EC=2.1.1.43; AltName: Full=PR domain zinc finger protein 6; AltName: Full=PR domain-containing protein 6; FUNCTION: Putative histone methyltransferase that acts as a transcriptional repressor of smooth muscle gene expression. Promotes the transition from differentiated to proliferative smooth muscle by suppressing differentiation and maintaining the proliferative potential of vascular smooth muscle cells. Also plays a role in endothelial cells by inhibiting endothelial cell proliferation, survival and differentiation. It is unclear whether it has histone methyltransferase activity in vivo. According to some authors, it does not act as a histone methyltransferase by itself and represses transcription by recruiting EHMT2/G9a. According to others, it possesses histone methyltransferase activity when associated with other proteins and specifically methylates 'Lys-20' of histone H4 in vitro. 'Lys-20' methylation represents a specific tag for epigenetic transcriptional repression (By similarity). CATALYTIC ACTIVITY: S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone]. SUBUNIT: Interacts with HDAC1, HDAC2, HDAC3, CBX1 and EP300 (By similarity). SUBCELLULAR LOCATION: Nucleus (By similarity). SIMILARITY: Contains 4 C2H2-type zinc fingers. SIMILARITY: Contains 1 SET domain. SEQUENCE CAUTION: Sequence=AAF78078.1; Type=Erroneous initiation; Sequence=AAF78079.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00856 - SET domain PF00096 - Zinc finger, C2H2 type
ModBase Predicted Comparative 3D Structure on Q9NQX0
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.