Human Gene NRG2 (ENST00000358522.7) from GENCODE V44
Description: Homo sapiens neuregulin 2 (NRG2), transcript variant 4, mRNA. (from RefSeq NM_013983) RefSeq Summary (NM_013983): This gene encodes a novel member of the neuregulin family of growth and differentiation factors. Through interaction with the ERBB family of receptors, this protein induces the growth and differentiation of epithelial, neuronal, glial, and other types of cells. The gene consists of 12 exons and the genomic structure is similar to that of neuregulin 1, another member of the neuregulin family of ligands. The products of these genes mediate distinct biological processes by acting at different sites in tissues and eliciting different biological responses in cells. This gene is located close to the region for demyelinating Charcot-Marie-Tooth disease locus, but is not responsible for this disease. Alternative transcript variants encoding distinct isoforms have been described. [provided by RefSeq, May 2010]. Gencode Transcript: ENST00000358522.7 Gencode Gene: ENSG00000158458.21 Transcript (Including UTRs) Position: hg38 chr5:139,847,917-140,043,069 Size: 195,153 Total Exon Count: 11 Strand: - Coding Region Position: hg38 chr5:139,847,917-140,043,069 Size: 195,153 Coding Exon Count: 11
ID:NRG2_HUMAN DESCRIPTION: RecName: Full=Pro-neuregulin-2, membrane-bound isoform; Short=Pro-NRG2; Contains: RecName: Full=Neuregulin-2; Short=NRG-2; AltName: Full=Divergent of neuregulin-1; Short=DON-1; AltName: Full=Neural- and thymus-derived activator for ERBB kinases; Short=NTAK; Flags: Precursor; FUNCTION: Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. May also promote the heterodimerization with the EGF receptor. SUBUNIT: Interacts with ERBB3 and ERBB4. SUBCELLULAR LOCATION: Pro-neuregulin-2, membrane-bound isoform: Cell membrane; Single-pass type I membrane protein (By similarity). Note=Does not seem to be active (By similarity). SUBCELLULAR LOCATION: Neuregulin-2: Secreted (By similarity). TISSUE SPECIFICITY: Restricted to the cerebellum in the adult. DOMAIN: The cytoplasmic domain may be involved in the regulation of trafficking and proteolytic processing. Regulation of the proteolytic processing involves initial intracellular domain dimerization (By similarity). DOMAIN: ERBB receptor binding is elicited entirely by the EGF-like domain (By similarity). PTM: Proteolytic cleavage close to the plasma membrane on the external face leads to the release of the soluble growth factor form (By similarity). PTM: Extensive glycosylation precedes the proteolytic cleavage (By similarity). SIMILARITY: Belongs to the neuregulin family. SIMILARITY: Contains 1 EGF-like domain. SIMILARITY: Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
ModBase Predicted Comparative 3D Structure on O14511
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0000165 MAPK cascade GO:0007165 signal transduction GO:0010469 regulation of receptor activity GO:0018108 peptidyl-tyrosine phosphorylation GO:0035556 intracellular signal transduction GO:0038128 ERBB2 signaling pathway GO:0046854 phosphatidylinositol phosphorylation GO:0048513 animal organ development GO:0051897 positive regulation of protein kinase B signaling GO:2000145 regulation of cell motility