Human Gene MYOZ3 (ENST00000297130.4) from GENCODE V44
Description: Homo sapiens myozenin 3 (MYOZ3), transcript variant 2, mRNA. (from RefSeq NM_133371) RefSeq Summary (NM_133371): The protein encoded by this gene is specifically expressed in the skeletal muscle, and belongs to the myozenin family. Members of this family function as calcineurin-interacting proteins that help tether calcineurin to the sarcomere of cardiac and skeletal muscle. They play an important role in modulation of calcineurin signaling. [provided by RefSeq, Apr 2012]. Gencode Transcript: ENST00000297130.4 Gencode Gene: ENSG00000164591.14 Transcript (Including UTRs) Position: hg38 chr5:150,660,882-150,679,365 Size: 18,484 Total Exon Count: 7 Strand: + Coding Region Position: hg38 chr5:150,662,942-150,676,875 Size: 13,934 Coding Exon Count: 6
ID:MYOZ3_HUMAN DESCRIPTION: RecName: Full=Myozenin-3; AltName: Full=Calsarcin-3; AltName: Full=FATZ-related protein 3; FUNCTION: Myozenins may serve as intracellular binding proteins involved in linking Z line proteins such as alpha-actinin, gamma- filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis. SUBUNIT: Interacts with ACTN2, LDB3, FLNC, PPP3CA and TCAP. SUBCELLULAR LOCATION: Cytoplasm, myofibril, sarcomere, Z line (By similarity). Note=Localized at the Z-line of skeletal muscle (By similarity). TISSUE SPECIFICITY: Expressed specifically in skeletal muscle. Not detected in heart. SIMILARITY: Belongs to the myozenin family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF05556 - Calcineurin-binding protein (Calsarcin)
ModBase Predicted Comparative 3D Structure on Q8TDC0
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Microarray Expression Data 
