Human Gene MAT2B (ENST00000280969.9) from GENCODE V44
Description: Homo sapiens methionine adenosyltransferase 2B (MAT2B), transcript variant 2, mRNA. (from RefSeq NM_182796) RefSeq Summary (NM_182796): The protein encoded by this gene belongs to the methionine adenosyltransferase (MAT) family. MAT catalyzes the biosynthesis of S-adenosylmethionine from methionine and ATP. This protein is the regulatory beta subunit of MAT. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2012]. Gencode Transcript: ENST00000280969.9 Gencode Gene: ENSG00000038274.18 Transcript (Including UTRs) Position: hg38 chr5:163,503,114-163,519,336 Size: 16,223 Total Exon Count: 7 Strand: + Coding Region Position: hg38 chr5:163,503,395-163,518,363 Size: 14,969 Coding Exon Count: 7
ID:MAT2B_HUMAN DESCRIPTION: RecName: Full=Methionine adenosyltransferase 2 subunit beta; AltName: Full=Methionine adenosyltransferase II beta; Short=MAT II beta; AltName: Full=Putative dTDP-4-keto-6-deoxy-D-glucose 4-reductase; FUNCTION: Non-catalytic regulatory subunit of S-adenosylmethionine synthetase 2 (MAT2A), an enzyme that catalyzes the formation of S- adenosylmethionine from methionine and ATP. Regulates the activity of S-adenosylmethionine synthetase 2 by changing its kinetic properties, rendering the enzyme more susceptible to S- adenosylmethionine inhibition. PATHWAY: Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1. SUBUNIT: Heterotetramer composed of 2 catalytic alpha subunits (alpha and alpha') (MAT2A) and 1 copy of beta subunit (MAT2B). TISSUE SPECIFICITY: Widely expressed. MISCELLANEOUS: Its expression in hepatoma cell lines may lead to increase DNA synthesis and thereby participate in cell proliferation. SIMILARITY: Belongs to the dTDP-4-dehydrorhamnose reductase family. MAT2B subfamily. SEQUENCE CAUTION: Sequence=AAG39296.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9NZL9
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006556 S-adenosylmethionine biosynthetic process GO:0006730 one-carbon metabolic process GO:0050790 regulation of catalytic activity