Human Gene DUSP1 (ENST00000239223.4) from GENCODE V44
Description: Homo sapiens dual specificity phosphatase 1 (DUSP1), mRNA. (from RefSeq NM_004417) RefSeq Summary (NM_004417): The protein encoded by this gene is a phosphatase with dual specificity for tyrosine and threonine. The encoded protein can dephosphorylate MAP kinase MAPK1/ERK2, which results in its involvement in several cellular processes. This protein appears to play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation. Finally, the encoded protein can make some solid tumors resistant to both chemotherapy and radiotherapy, making it a target for cancer therapy. [provided by RefSeq, Aug 2017]. Gencode Transcript: ENST00000239223.4 Gencode Gene: ENSG00000120129.6 Transcript (Including UTRs) Position: hg38 chr5:172,768,096-172,771,195 Size: 3,100 Total Exon Count: 4 Strand: - Coding Region Position: hg38 chr5:172,768,762-172,770,952 Size: 2,191 Coding Exon Count: 4
ID:DUS1_HUMAN DESCRIPTION: RecName: Full=Dual specificity protein phosphatase 1; EC=3.1.3.16; EC=3.1.3.48; AltName: Full=Dual specificity protein phosphatase hVH1; AltName: Full=Mitogen-activated protein kinase phosphatase 1; Short=MAP kinase phosphatase 1; Short=MKP-1; AltName: Full=Protein-tyrosine phosphatase CL100; FUNCTION: Dual specificity phosphatase that dephosphorylates MAP kinase MAPK1/ERK2 on both 'Thr-183' and 'Tyr-185'. CATALYTIC ACTIVITY: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate. CATALYTIC ACTIVITY: A phosphoprotein + H(2)O = a protein + phosphate. INTERACTION: P28482:MAPK1; NbExp=3; IntAct=EBI-975493, EBI-959949; Q13309:SKP2; NbExp=3; IntAct=EBI-975493, EBI-456291; P0CG47:UBB; NbExp=2; IntAct=EBI-975493, EBI-413034; TISSUE SPECIFICITY: Expressed at high levels in the lung, liver placenta and pancreas. Moderate levels seen in the heart and skeletal muscle. Lower levels found in the brain and kidney. INDUCTION: By oxidative stress and heat shock. PTM: Phosphorylation at Ser-359 and Ser-364 by MAPK1/ERK2 and MAPK3/ERK1 reduces its rate of degradation (By similarity). SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. SIMILARITY: Contains 1 rhodanese domain. SIMILARITY: Contains 1 tyrosine-protein phosphatase domain. WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/dusp1/";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P28562
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0004721 phosphoprotein phosphatase activity GO:0004725 protein tyrosine phosphatase activity GO:0004726 non-membrane spanning protein tyrosine phosphatase activity GO:0005515 protein binding GO:0008138 protein tyrosine/serine/threonine phosphatase activity GO:0008330 protein tyrosine/threonine phosphatase activity GO:0016787 hydrolase activity GO:0016791 phosphatase activity GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity GO:0019838 growth factor binding
Biological Process: GO:0000188 inactivation of MAPK activity GO:0001706 endoderm formation GO:0006470 protein dephosphorylation GO:0006979 response to oxidative stress GO:0007049 cell cycle GO:0008285 negative regulation of cell proliferation GO:0009416 response to light stimulus GO:0010033 response to organic substance GO:0016311 dephosphorylation GO:0032355 response to estradiol GO:0032526 response to retinoic acid GO:0032870 cellular response to hormone stimulus GO:0033574 response to testosterone GO:0035335 peptidyl-tyrosine dephosphorylation GO:0035556 intracellular signal transduction GO:0035970 peptidyl-threonine dephosphorylation GO:0042542 response to hydrogen peroxide GO:0042981 regulation of apoptotic process GO:0043065 positive regulation of apoptotic process GO:0043066 negative regulation of apoptotic process GO:0043407 negative regulation of MAP kinase activity GO:0043409 negative regulation of MAPK cascade GO:0051384 response to glucocorticoid GO:0051447 negative regulation of meiotic cell cycle GO:0051591 response to cAMP GO:0051592 response to calcium ion GO:0070262 peptidyl-serine dephosphorylation GO:0070373 negative regulation of ERK1 and ERK2 cascade GO:0071850 mitotic cell cycle arrest GO:0090266 regulation of mitotic cell cycle spindle assembly checkpoint GO:2000279 negative regulation of DNA biosynthetic process
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