Human Gene EEF1E1 (ENST00000379715.10) from GENCODE V44
Description: Homo sapiens eukaryotic translation elongation factor 1 epsilon 1 (EEF1E1), transcript variant 1, mRNA. (from RefSeq NM_004280) RefSeq Summary (NM_004280): This gene encodes a multifunctional protein that localizes to both the cytoplasm and nucleus. In the cytoplasm, the encoded protein is an auxiliary component of the macromolecular aminoacyl-tRNA synthase complex. However, its mouse homolog has been shown to translocate to the nucleus in response to DNA damage, and it plays a positive role in ATM/ATR-mediated p53 activation. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream MUTED (muted homolog) gene. An EEF1E1-related pseudogene has been identified on chromosome 2. [provided by RefSeq, Dec 2010]. Gencode Transcript: ENST00000379715.10 Gencode Gene: ENSG00000124802.12 Transcript (Including UTRs) Position: hg38 chr6:8,079,395-8,102,548 Size: 23,154 Total Exon Count: 4 Strand: - Coding Region Position: hg38 chr6:8,079,890-8,102,521 Size: 22,632 Coding Exon Count: 4
ID:MCA3_HUMAN DESCRIPTION: RecName: Full=Eukaryotic translation elongation factor 1 epsilon-1; AltName: Full=Aminoacyl tRNA synthetase complex-interacting multifunctional protein 3; AltName: Full=Elongation factor p18; AltName: Full=Multisynthase complex auxiliary component p18; FUNCTION: Positive modulator of ATM response to DNA damage. SUBUNIT: Component of the multisynthase complex which is comprised of a bifunctional glutamyl-prolyl-tRNA synthase, the monospecific isoleucyl, leucyl, glutaminyl, methionyl, lysyl, arginyl and aspartyl-tRNA synthases, and three auxiliary proteins, EEF1E1/p18, AIMP2/p38 and AIMP1/p43. Interacts with ATM and ATR. The interaction with ATM, which takes place independently of TP53, is induced by DNA damage that may occur during genotoxic stress or cell growth. The interaction with ATR is enhanced by UV irradiation. INTERACTION: P04591:gag (xeno); NbExp=4; IntAct=EBI-1048486, EBI-6179719; SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Cytoplasmic under growth arrest conditions. Translocated into the nucleus when growth resumes (S phase) and following DNA damage. TISSUE SPECIFICITY: Down-regulated in various cancer tissues. INDUCTION: By DNA damaging agents such as UV, adriamycin, actinomycin-D and cisplatin. SIMILARITY: Contains 1 GST C-terminal domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O43324
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0004364 glutathione transferase activity GO:0005515 protein binding
Biological Process: GO:0006412 translation GO:0006418 tRNA aminoacylation for protein translation GO:0006749 glutathione metabolic process GO:0008285 negative regulation of cell proliferation GO:0043065 positive regulation of apoptotic process GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator GO:2000774 positive regulation of cellular senescence
US Server
