Human Gene KIF13A (ENST00000378814.9) from GENCODE V44
Description: Homo sapiens kinesin family member 13A (KIF13A), transcript variant 4, mRNA. (from RefSeq NM_001105568) RefSeq Summary (NM_001105568): This gene encodes a member of the kinesin family of microtubule-based motor proteins that function in the positioning of endosomes. This family member can direct mannose-6-phosphate receptor-containing vesicles from the trans-Golgi network to the plasma membrane, and it is necessary for the steady-state distribution of late endosomes/lysosomes. It is also required for the translocation of FYVE-CENT and TTC19 from the centrosome to the midbody during cytokinesis, and it plays a role in melanosome maturation. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2011]. Gencode Transcript: ENST00000378814.9 Gencode Gene: ENSG00000137177.20 Transcript (Including UTRs) Position: hg38 chr6:17,759,183-17,987,463 Size: 228,281 Total Exon Count: 38 Strand: - Coding Region Position: hg38 chr6:17,760,857-17,987,463 Size: 226,607 Coding Exon Count: 38
ID:KI13A_HUMAN DESCRIPTION: RecName: Full=Kinesin-like protein KIF13A; AltName: Full=Kinesin-like protein RBKIN; FUNCTION: Plus end-directed microtubule-dependent motor protein involved in intracellular transport and regulating various processes such as mannose-6-phosphate receptor (M6PR) transport to the plasma membrane, endosomal sorting during melanosome biogenesis and cytokinesis. Mediates the transport of M6PR- containing vesicles from trans-Golgi network to the plasma membrane via direct interaction with the AP-1 complex. During melanosome maturation, required for delivering melanogenic enzymes from recycling endosomes to nascent melanosomes by creating peripheral recycling endosomal subdomains in melanocytes. Also required for the abcission step in cytokinesis: mediates translocation of ZFYVE26, and possibly TTC19, to the midbody during cytokinesis. SUBUNIT: Interacts with AP2B1 (By similarity). Interacts with ZFYVE26. Interacts with AP1G1 and AP1G2. SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, centrosome. Midbody. Endosome membrane. Golgi apparatus membrane (By similarity). Note=Recruited to the midbody during cytokinesis. TISSUE SPECIFICITY: Widely expressed, with highest levels in heart, brain and skeletal muscle. DEVELOPMENTAL STAGE: Expressed at very low level in most fetal tissues, but at higher levels in skeletal muscle and lung. SIMILARITY: Belongs to the kinesin-like protein family. SIMILARITY: Contains 1 FHA domain. SIMILARITY: Contains 1 kinesin-motor domain. SEQUENCE CAUTION: Sequence=CAI21670.1; Type=Erroneous gene model prediction; Sequence=CAI21671.1; Type=Erroneous gene model prediction; Sequence=CAI40947.1; Type=Erroneous gene model prediction; Sequence=CAI40948.1; Type=Erroneous gene model prediction;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF12473 - Kinesin protein PF00498 - FHA domain PF12423 - Kinesin protein 1B PF00225 - Kinesin motor domain
ModBase Predicted Comparative 3D Structure on Q9H1H9
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006886 intracellular protein transport GO:0007018 microtubule-based movement GO:0007049 cell cycle GO:0008333 endosome to lysosome transport GO:0015031 protein transport GO:0030705 cytoskeleton-dependent intracellular transport GO:0032438 melanosome organization GO:0032465 regulation of cytokinesis GO:0035459 cargo loading into vesicle GO:0043001 Golgi to plasma membrane protein transport GO:0051301 cell division GO:0072383 plus-end-directed vesicle transport along microtubule
LP896415 - Sequence 1279 from Patent EP3253886. AJ291579 - Homo sapiens mRNA for KINESIN-13A2 (KIN13A gene). AK130742 - Homo sapiens cDNA FLJ27232 fis, clone SYN06360. AJ291578 - Homo sapiens mRNA for KINESIN-13A1 (KIN13A gene). AY014403 - Homo sapiens kinesin-like protein RBKIN1 (RBKIN) mRNA, complete cds, alternatively spliced. AY014404 - Homo sapiens kinesin-like protein RBKIN2 (RBKIN) mRNA, complete cds, alternatively spliced. BC127115 - Homo sapiens kinesin family member 13A, mRNA (cDNA clone MGC:150707 IMAGE:40125246), complete cds. BC127116 - Homo sapiens kinesin family member 13A, mRNA (cDNA clone MGC:150708 IMAGE:40125251), complete cds. BC001730 - Homo sapiens cDNA clone IMAGE:3353875, containing frame-shift errors. BC023613 - Homo sapiens cDNA clone IMAGE:4646849, containing frame-shift errors. BC062673 - Homo sapiens kinesin family member 13A, mRNA (cDNA clone IMAGE:6654466), with apparent retained intron. AK025303 - Homo sapiens cDNA: FLJ21650 fis, clone COL08516. AK225214 - Homo sapiens mRNA for kinesin family member 13A variant, clone: COL08516. JD336425 - Sequence 317449 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q9H1H9 (Reactome details) participates in the following event(s):
R-HSA-390470 Association of CCT/TriC with other substrates during biosynthesis (unknown chaperone) R-HSA-390471 Association of TriC/CCT with target proteins during biosynthesis R-HSA-390466 Chaperonin-mediated protein folding R-HSA-391251 Protein folding R-HSA-392499 Metabolism of proteins
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