Human Gene TRIM38 (ENST00000357085.5) Description and Page Index
Description: Homo sapiens tripartite motif containing 38 (TRIM38), mRNA. (from RefSeq NM_006355) RefSeq Summary (NM_006355): This gene encodes a member of the tripartite motif (TRIM) family. The encoded protein contains a RING-type zinc finger, B box-type zinc finger and SPRY domain. The function of this protein has not been identified. A pseudogene of this gene is located on the long arm of chromosome 4. [provided by RefSeq, Jul 2012]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Gencode Transcript: ENST00000357085.5 Gencode Gene: ENSG00000112343.11 Transcript (Including UTRs) Position: hg38 chr6:25,962,802-25,991,231 Size: 28,430 Total Exon Count: 8 Strand: + Coding Region Position: hg38 chr6:25,966,523-25,983,687 Size: 17,165 Coding Exon Count: 6
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O00635
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0002376 immune system process GO:0016567 protein ubiquitination GO:0032648 regulation of interferon-beta production GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0045070 positive regulation of viral genome replication GO:0045087 innate immune response GO:0046598 positive regulation of viral entry into host cell GO:0050687 negative regulation of defense response to virus GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051092 positive regulation of NF-kappaB transcription factor activity GO:0060333 interferon-gamma-mediated signaling pathway GO:0070936 protein K48-linked ubiquitination