Human Gene ZSCAN23 (ENST00000289788.5) from GENCODE V44
  Description: Homo sapiens zinc finger and SCAN domain containing 23 (ZSCAN23), mRNA. (from RefSeq NM_001012455)
Gencode Transcript: ENST00000289788.5
Gencode Gene: ENSG00000187987.10
Transcript (Including UTRs)
   Position: hg38 chr6:28,432,655-28,443,491 Size: 10,837 Total Exon Count: 4 Strand: -
Coding Region
   Position: hg38 chr6:28,434,465-28,436,266 Size: 1,802 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr6:28,432,655-28,443,491)mRNA (may differ from genome)Protein (389 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards
HGNCHPRDMalacardsMGIneXtProtPubMed
UniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: ZSC23_HUMAN
DESCRIPTION: RecName: Full=Zinc finger and SCAN domain-containing protein 23; AltName: Full=Zinc finger protein 390; AltName: Full=Zinc finger protein 453;
FUNCTION: May be involved in transcriptional regulation.
SUBCELLULAR LOCATION: Nucleus (Potential).
SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein family.
SIMILARITY: Contains 5 C2H2-type zinc fingers.
SIMILARITY: Contains 1 SCAN box domain.
SEQUENCE CAUTION: Sequence=CAC44641.1; Type=Erroneous gene model prediction;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 0.87 RPKM in Ovary
Total median expression: 14.55 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -48.00170-0.282 Picture PostScript Text
3' UTR -368.801810-0.204 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR008916 - Retrov_capsid_C
IPR003309 - Tscrpt_reg_SCAN
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd

Pfam Domains:
PF02023 - SCAN domain

ModBase Predicted Comparative 3D Structure on Q3MJ62
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003700 transcription factor activity, sequence-specific DNA binding
GO:0046872 metal ion binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter

Cellular Component:
GO:0005634 nucleus


-  Descriptions from all associated GenBank mRNAs
  AK092117 - Homo sapiens cDNA FLJ34798 fis, clone NT2NE2006103, moderately similar to ZINC FINGER PROTEIN 165.
AX747363 - Sequence 888 from Patent EP1308459.
AK309235 - Homo sapiens cDNA, FLJ99276.
AL833347 - Homo sapiens mRNA; cDNA DKFZp686O1534 (from clone DKFZp686O1534).
JD238709 - Sequence 219733 from Patent EP1572962.
JD181889 - Sequence 162913 from Patent EP1572962.
JD202840 - Sequence 183864 from Patent EP1572962.
JD346910 - Sequence 327934 from Patent EP1572962.
JD120209 - Sequence 101233 from Patent EP1572962.
JD058988 - Sequence 40012 from Patent EP1572962.
JD350243 - Sequence 331267 from Patent EP1572962.
JD280547 - Sequence 261571 from Patent EP1572962.
JD354781 - Sequence 335805 from Patent EP1572962.
JD528401 - Sequence 509425 from Patent EP1572962.
BC101557 - Homo sapiens zinc finger and SCAN domain containing 23, mRNA (cDNA clone MGC:126606 IMAGE:8069063), complete cds.
BC101559 - Homo sapiens zinc finger and SCAN domain containing 23, mRNA (cDNA clone MGC:126608 IMAGE:8069065), complete cds.
BC143560 - Homo sapiens cDNA clone IMAGE:9052071, with apparent retained intron.
EU446684 - Synthetic construct Homo sapiens clone IMAGE:100069795; IMAGE:100011893; FLH258559.01L zinc finger and SCAN domain containing 23 (ZSCAN23) gene, encodes complete protein.
DQ594108 - Homo sapiens piRNA piR-60220, complete sequence.
DQ586345 - Homo sapiens piRNA piR-53457, complete sequence.
JD419829 - Sequence 400853 from Patent EP1572962.
JD267693 - Sequence 248717 from Patent EP1572962.
JD074229 - Sequence 55253 from Patent EP1572962.
JD423297 - Sequence 404321 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000289788.1, ENST00000289788.2, ENST00000289788.3, ENST00000289788.4, NM_001012455, Q3MJ62, Q96KV9, uc003nli.1, uc003nli.2, uc003nli.3, uc003nli.4, uc003nli.5, uc003nli.6, ZNF390, ZNF453, ZSC23_HUMAN
UCSC ID: ENST00000289788.5
RefSeq Accession: NM_001012455
Protein: Q3MJ62 (aka ZSC23_HUMAN)

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.