Human Gene TRIM10 (ENST00000449742.7) Description and Page Index
  Description: Homo sapiens tripartite motif containing 10 (TRIM10), transcript variant 1, mRNA. (from RefSeq NM_006778)
RefSeq Summary (NM_006778): The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to cytoplasmic bodies. Studies in mice suggest that this protein plays a role in terminal differentiation of erythroid cells. Alternate splicing of this gene generates two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].
Gencode Transcript: ENST00000449742.7
Gencode Gene: ENSG00000204613.11
Transcript (Including UTRs)
   Position: hg38 chr6:30,151,943-30,161,211 Size: 9,269 Total Exon Count: 7 Strand: -
Coding Region
   Position: hg38 chr6:30,153,969-30,160,858 Size: 6,890 Coding Exon Count: 7 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsPathways
Other NamesMethods
Data last updated at UCSC: 2019-09-04

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr6:30,151,943-30,161,211)mRNA (may differ from genome)Protein (481 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC
HPRDLynxMGIneXtProtOMIMPubMed
ReactomeUniProtKB

-  Comments and Description Text from UniProtKB
  ID: TRI10_HUMAN
DESCRIPTION: RecName: Full=Tripartite motif-containing protein 10; AltName: Full=B30-RING finger protein; AltName: Full=RING finger protein 9;
FUNCTION: Seems to play an important role in erythropoiesis (By similarity).
SUBCELLULAR LOCATION: Cytoplasm.
SIMILARITY: Belongs to the TRIM/RBCC family.
SIMILARITY: Contains 1 B box-type zinc finger.
SIMILARITY: Contains 1 B30.2/SPRY domain.
SIMILARITY: Contains 1 RING-type zinc finger.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 1.72 RPKM in Colon - Transverse
Total median expression: 7.10 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -117.70353-0.333 Picture PostScript Text
3' UTR -619.302026-0.306 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001870 - B30.2/SPRY
IPR003879 - Butyrophylin
IPR008985 - ConA-like_lec_gl_sf
IPR006574 - PRY
IPR018355 - SPla/RYanodine_receptor_subgr
IPR003877 - SPRY_rcpt
IPR000315 - Znf_B-box
IPR001841 - Znf_RING
IPR013083 - Znf_RING/FYVE/PHD
IPR017907 - Znf_RING_CS

Pfam Domains:
PF00622 - SPRY domain
PF00643 - B-box zinc finger

ModBase Predicted Comparative 3D Structure on Q9UDY6
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003674 molecular_function
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0046872 metal ion binding

Biological Process:
GO:0008150 biological_process
GO:0030218 erythrocyte differentiation
GO:0045087 innate immune response
GO:0046597 negative regulation of viral entry into host cell

Cellular Component:
GO:0005622 intracellular
GO:0005737 cytoplasm


-  Descriptions from all associated GenBank mRNAs
  AL360163 - Homo sapiens mRNA full length insert cDNA clone EUROIMAGE 209789.
AF220123 - Homo sapiens tripartite motif protein TRIM10 beta (TRIM10) mRNA, complete cds; alternatively spliced.
JD238826 - Sequence 219850 from Patent EP1572962.
JD211962 - Sequence 192986 from Patent EP1572962.
JD544837 - Sequence 525861 from Patent EP1572962.
JD198657 - Sequence 179681 from Patent EP1572962.
JD065283 - Sequence 46307 from Patent EP1572962.
JD087188 - Sequence 68212 from Patent EP1572962.
JD086600 - Sequence 67624 from Patent EP1572962.
JD245509 - Sequence 226533 from Patent EP1572962.
JD379340 - Sequence 360364 from Patent EP1572962.
JD315283 - Sequence 296307 from Patent EP1572962.
JD333713 - Sequence 314737 from Patent EP1572962.
JD222554 - Sequence 203578 from Patent EP1572962.
JD343873 - Sequence 324897 from Patent EP1572962.
JD249321 - Sequence 230345 from Patent EP1572962.
JD137204 - Sequence 118228 from Patent EP1572962.
JD237971 - Sequence 218995 from Patent EP1572962.
JD295631 - Sequence 276655 from Patent EP1572962.
JD119929 - Sequence 100953 from Patent EP1572962.
JD063437 - Sequence 44461 from Patent EP1572962.
JD242282 - Sequence 223306 from Patent EP1572962.
JD146333 - Sequence 127357 from Patent EP1572962.
JD427523 - Sequence 408547 from Patent EP1572962.
JD414629 - Sequence 395653 from Patent EP1572962.
Y13935 - Homo sapiens mRNA; clone CD 235.
JD421843 - Sequence 402867 from Patent EP1572962.
JD426551 - Sequence 407575 from Patent EP1572962.
JD247580 - Sequence 228604 from Patent EP1572962.
JD116787 - Sequence 97811 from Patent EP1572962.
JD189676 - Sequence 170700 from Patent EP1572962.
JD405144 - Sequence 386168 from Patent EP1572962.
JD057106 - Sequence 38130 from Patent EP1572962.
JD173398 - Sequence 154422 from Patent EP1572962.
JD387564 - Sequence 368588 from Patent EP1572962.
JD085957 - Sequence 66981 from Patent EP1572962.
JD317262 - Sequence 298286 from Patent EP1572962.
JD539378 - Sequence 520402 from Patent EP1572962.
JD400374 - Sequence 381398 from Patent EP1572962.
JD105482 - Sequence 86506 from Patent EP1572962.
JD488703 - Sequence 469727 from Patent EP1572962.
JD043707 - Sequence 24731 from Patent EP1572962.
AL360164 - Homo sapiens mRNA full length insert cDNA clone EUROIMAGE 234457.
AF220122 - Homo sapiens tripartite motif protein TRIM10 alpha (TRIM10) mRNA, complete cds; alternatively spliced.
JD454222 - Sequence 435246 from Patent EP1572962.
JD322355 - Sequence 303379 from Patent EP1572962.
BC093926 - Homo sapiens tripartite motif-containing 10, mRNA (cDNA clone MGC:120961 IMAGE:7939771), complete cds.
BC113419 - Homo sapiens tripartite motif-containing 10, mRNA (cDNA clone MGC:141979 IMAGE:8322471), complete cds.
JD060459 - Sequence 41483 from Patent EP1572962.
HQ258220 - Synthetic construct Homo sapiens clone IMAGE:100072529 Unknown protein gene, encodes complete protein.
KJ898159 - Synthetic construct Homo sapiens clone ccsbBroadEn_07553 TRIM10 gene, encodes complete protein.
JD276548 - Sequence 257572 from Patent EP1572962.
JD290101 - Sequence 271125 from Patent EP1572962.
L19497 - Human (clone CAT72-Fan) MHC mRNA, partial cds.
JD370889 - Sequence 351913 from Patent EP1572962.
JD144308 - Sequence 125332 from Patent EP1572962.
JD396833 - Sequence 377857 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q9UDY6 (Reactome details) participates in the following event(s):

R-HSA-877300 Interferon gamma signaling
R-HSA-913531 Interferon Signaling
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-168256 Immune System

-  Other Names for This Gene
  Alternate Gene Symbols: A6NF84, NM_006778, Q5SRJ5, Q5SRK8, Q86Z08, Q96QB6, Q9C023, Q9C024, Q9UDY6, RFB30, RNF9, TRI10_HUMAN, uc003npo.1, uc003npo.2, uc003npo.3, uc003npo.4, uc003npo.5
UCSC ID: uc003npo.5
RefSeq Accession: NM_006778
Protein: Q9UDY6 (aka TRI10_HUMAN or TRMA_HUMAN)
CCDS: CCDS34375.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.