Human Gene TRIM26 (ENST00000454678.7) Description and Page Index
  Description: Homo sapiens tripartite motif containing 26 (TRIM26), transcript variant 1, mRNA. (from RefSeq NM_003449)
RefSeq Summary (NM_003449): The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies. Although the function of the protein is unknown, the RING domain suggests that the protein may have DNA-binding activity. The gene localizes to the major histocompatibility complex (MHC) class I region on chromosome 6. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jun 2011].
Gencode Transcript: ENST00000454678.7
Gencode Gene: ENSG00000234127.9
Transcript (Including UTRs)
   Position: hg38 chr6:30,184,455-30,213,406 Size: 28,952 Total Exon Count: 10 Strand: -
Coding Region
   Position: hg38 chr6:30,185,876-30,199,103 Size: 13,228 Coding Exon Count: 7 

Page IndexSequence and LinksUniProtKB CommentsMalaCardsCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesMethods
Data last updated at UCSC: 2019-09-04

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr6:30,184,455-30,213,406)mRNA (may differ from genome)Protein (539 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Tripartite motif-containing protein 26; AltName: Full=Acid finger protein; Short=AFP; AltName: Full=RING finger protein 95; AltName: Full=Zinc finger protein 173;
SIMILARITY: Belongs to the TRIM/RBCC family.
SIMILARITY: Contains 1 B box-type zinc finger.
SIMILARITY: Contains 1 B30.2/SPRY domain.
SIMILARITY: Contains 1 RING-type zinc finger.

-  MalaCards Disease Associations
  MalaCards Gene Search: TRIM26
Diseases sorted by gene-association score: neural tube defects (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 27.72 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 690.02 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -175.60477-0.368 Picture PostScript Text
3' UTR -450.201421-0.317 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001870 - B30.2/SPRY
IPR003879 - Butyrophylin
IPR008985 - ConA-like_lec_gl_sf
IPR006574 - PRY
IPR018355 - SPla/RYanodine_receptor_subgr
IPR003877 - SPRY_rcpt
IPR000315 - Znf_B-box
IPR001841 - Znf_RING

Pfam Domains:
PF00622 - SPRY domain
PF00643 - B-box zinc finger

ModBase Predicted Comparative 3D Structure on Q12899
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016740 transferase activity
GO:0046872 metal ion binding

Biological Process:
GO:0002376 immune system process
GO:0045087 innate immune response
GO:0046597 negative regulation of viral entry into host cell
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity
GO:0060333 interferon-gamma-mediated signaling pathway
GO:1902187 negative regulation of viral release from host cell

Cellular Component:
GO:0005575 cellular_component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol

-  Descriptions from all associated GenBank mRNAs
  BC021115 - Homo sapiens tripartite motif-containing 26, mRNA (cDNA clone IMAGE:5094007), with apparent retained intron.
BC032297 - Homo sapiens tripartite motif-containing 26, mRNA (cDNA clone MGC:40232 IMAGE:4938971), complete cds.
BC024039 - Homo sapiens tripartite motif-containing 26, mRNA (cDNA clone MGC:12710 IMAGE:3954669), complete cds.
JD079105 - Sequence 60129 from Patent EP1572962.
JD242391 - Sequence 223415 from Patent EP1572962.
JD345828 - Sequence 326852 from Patent EP1572962.
U09825 - Human acid finger protein mRNA, complete cds.
AK122859 - Homo sapiens cDNA FLJ16483 fis, clone BRTHA3002265, highly similar to Human acid finger protein mRNA.
AK096996 - Homo sapiens cDNA FLJ39677 fis, clone SMINT2009973, highly similar to Human acid finger protein mRNA.
JD274816 - Sequence 255840 from Patent EP1572962.
JD281163 - Sequence 262187 from Patent EP1572962.
JD363854 - Sequence 344878 from Patent EP1572962.
JD233352 - Sequence 214376 from Patent EP1572962.
JD428045 - Sequence 409069 from Patent EP1572962.
JD362724 - Sequence 343748 from Patent EP1572962.
JD122869 - Sequence 103893 from Patent EP1572962.
JD415656 - Sequence 396680 from Patent EP1572962.
JD096159 - Sequence 77183 from Patent EP1572962.
JD043040 - Sequence 24064 from Patent EP1572962.
JD496609 - Sequence 477633 from Patent EP1572962.
JD152630 - Sequence 133654 from Patent EP1572962.
JD375884 - Sequence 356908 from Patent EP1572962.
JD267360 - Sequence 248384 from Patent EP1572962.
JD540658 - Sequence 521682 from Patent EP1572962.
JD325044 - Sequence 306068 from Patent EP1572962.
JD164767 - Sequence 145791 from Patent EP1572962.
JD206115 - Sequence 187139 from Patent EP1572962.
JD181311 - Sequence 162335 from Patent EP1572962.
LF341396 - JP 2014500723-A/148899: Polycomb-Associated Non-Coding RNAs.
MA576973 - JP 2018138019-A/148899: Polycomb-Associated Non-Coding RNAs.
JD539442 - Sequence 520466 from Patent EP1572962.
JD508696 - Sequence 489720 from Patent EP1572962.
JD325653 - Sequence 306677 from Patent EP1572962.
JD478996 - Sequence 460020 from Patent EP1572962.
JD147881 - Sequence 128905 from Patent EP1572962.
JD439564 - Sequence 420588 from Patent EP1572962.
AK314782 - Homo sapiens cDNA, FLJ95652.
LF341395 - JP 2014500723-A/148898: Polycomb-Associated Non-Coding RNAs.
MA576972 - JP 2018138019-A/148898: Polycomb-Associated Non-Coding RNAs.
LF341394 - JP 2014500723-A/148897: Polycomb-Associated Non-Coding RNAs.
MA576971 - JP 2018138019-A/148897: Polycomb-Associated Non-Coding RNAs.
LF341393 - JP 2014500723-A/148896: Polycomb-Associated Non-Coding RNAs.
MA576970 - JP 2018138019-A/148896: Polycomb-Associated Non-Coding RNAs.
LF341392 - JP 2014500723-A/148895: Polycomb-Associated Non-Coding RNAs.
MA576969 - JP 2018138019-A/148895: Polycomb-Associated Non-Coding RNAs.
CU689318 - Synthetic construct Homo sapiens gateway clone IMAGE:100019819 5' read TRIM26 mRNA.
LF341391 - JP 2014500723-A/148894: Polycomb-Associated Non-Coding RNAs.
MA576968 - JP 2018138019-A/148894: Polycomb-Associated Non-Coding RNAs.
JD364926 - Sequence 345950 from Patent EP1572962.
JD133366 - Sequence 114390 from Patent EP1572962.
JD322329 - Sequence 303353 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q12899 (Reactome details) participates in the following event(s):

R-HSA-877300 Interferon gamma signaling
R-HSA-913531 Interferon Signaling
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-168256 Immune System

-  Other Names for This Gene
  Alternate Gene Symbols: A6NG96, NM_003449, Q12899, Q5SRL2, RNF95, TRI26_HUMAN, uc003nps.1, uc003nps.2, uc003nps.3, uc003nps.4, uc003nps.5, ZNF173
UCSC ID: uc003nps.5
RefSeq Accession: NM_003449
Protein: Q12899 (aka TRI26_HUMAN or TM26_HUMAN)
CCDS: CCDS4678.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.