Human Gene VARS2 (ENST00000321897.9) from GENCODE V44
Description: Homo sapiens valyl-tRNA synthetase 2, mitochondrial (VARS2), transcript variant 1, mRNA; nuclear gene for mitochondrial product. (from RefSeq NM_001167734) RefSeq Summary (NM_001167734): This gene encodes a mitochondrial aminoacyl-tRNA synthetase, which catalyzes the attachment of valine to tRNA(Val) for mitochondrial translation. Mutations in this gene cause combined oxidative phosphorylation deficiency-20, and are also associated with early-onset mitochondrial encephalopathies. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2014]. Gencode Transcript: ENST00000321897.9 Gencode Gene: ENSG00000137411.19 Transcript (Including UTRs) Position: hg38 chr6:30,914,205-30,926,459 Size: 12,255 Total Exon Count: 29 Strand: + Coding Region Position: hg38 chr6:30,914,837-30,926,210 Size: 11,374 Coding Exon Count: 29
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF08264 - Anticodon-binding domain of tRNA PF00133 - tRNA synthetases class I (I, L, M and V)
ModBase Predicted Comparative 3D Structure on Q5ST30
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
