Human Gene C6orf15 (ENST00000259870.4) from GENCODE V44
  Description: Homo sapiens chromosome 6 open reading frame 15 (C6orf15), mRNA. (from RefSeq NM_014070)
Gencode Transcript: ENST00000259870.4
Gencode Gene: ENSG00000204542.3
Transcript (Including UTRs)
   Position: hg38 chr6:31,111,223-31,112,575 Size: 1,353 Total Exon Count: 2 Strand: -
Coding Region
   Position: hg38 chr6:31,111,381-31,112,555 Size: 1,175 Coding Exon Count: 2 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr6:31,111,223-31,112,575)mRNA (may differ from genome)Protein (325 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards
HGNCHPRDLynxMalacardsMGIneXtProt
OMIMPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: CF015_HUMAN
DESCRIPTION: RecName: Full=Uncharacterized protein C6orf15; AltName: Full=Protein STG; Flags: Precursor;
SUBUNIT: Binds to numerous extracellular matrix proteins (By similarity).
SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix (By similarity).
TISSUE SPECIFICITY: Expressed in skin and tonsils.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: C6orf15
Diseases sorted by gene-association score: posterior cerebral artery infarction (17), gastric body carcinoma (16), avoidant personality disorder (7), toxic diffuse goiter (7)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 3.97 RPKM in Skin - Sun Exposed (Lower leg)
Total median expression: 7.21 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -0.8020-0.040 Picture PostScript Text
3' UTR -40.30158-0.255 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR026135 - C6orf15

ModBase Predicted Comparative 3D Structure on Q6UXA7
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGI     
Protein Sequence     
Alignment     

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003674 molecular_function

Biological Process:
GO:0008150 biological_process

Cellular Component:
GO:0005575 cellular_component
GO:0005576 extracellular region


-  Descriptions from all associated GenBank mRNAs
  AB031481 - Homo sapiens STG mRNA, complete cds.
AY358438 - Homo sapiens clone DNA59844 STG (UNQ1840) mRNA, complete cds.
JD423608 - Sequence 404632 from Patent EP1572962.
JD361419 - Sequence 342443 from Patent EP1572962.
BC153157 - Synthetic construct Homo sapiens clone IMAGE:100016572, MGC:184235 chromosome 6 open reading frame 15 (C6orf15) mRNA, encodes complete protein.
BC146374 - Synthetic construct Homo sapiens clone IMAGE:100015156, MGC:180226 chromosome 6 open reading frame 15 (C6orf15) mRNA, encodes complete protein.
AB463524 - Synthetic construct DNA, clone: pF1KB7398, Homo sapiens C6orf15 gene for chromosome 6 open reading frame 15, without stop codon, in Flexi system.
BC114611 - Homo sapiens cDNA clone IMAGE:40023335.

-  Other Names for This Gene
  Alternate Gene Symbols: B0S7V8, CF015_HUMAN, ENST00000259870.1, ENST00000259870.2, ENST00000259870.3, NM_014070, Q0EFA6, Q2L6G7, Q5SQ81, Q6UXA7, Q86Z05, Q9UIG3, STG, uc003nsk.1, uc003nsk.2, uc003nsk.3, UNQ1840/PRO3566
UCSC ID: ENST00000259870.4
RefSeq Accession: NM_014070
Protein: Q6UXA7 (aka CF015_HUMAN)
CCDS: CCDS4693.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.