Human Gene PFDN6 (ENST00000374607.5) from GENCODE V44
  Description: Homo sapiens prefoldin subunit 6 (PFDN6), transcript variant 2, mRNA. (from RefSeq NM_014260)
RefSeq Summary (NM_014260): PFDN6 is a subunit of the heteromeric prefoldin complex that chaperones nascent actin (see MIM 102560) and alpha- and beta-tubulin (see MIM 602529 and MIM 191130, respectively) chains pending their transfer to the cytosolic chaperonin containing TCP1 (MIM 186980) (CCT) complex (Hansen et al., 1999 [PubMed 10209023]).[supplied by OMIM, Jul 2010].
Gencode Transcript: ENST00000374607.5
Gencode Gene: ENSG00000204220.12
Transcript (Including UTRs)
   Position: hg38 chr6:33,289,597-33,290,934 Size: 1,338 Total Exon Count: 5 Strand: +
Coding Region
   Position: hg38 chr6:33,289,857-33,290,845 Size: 989 Coding Exon Count: 4 

Page IndexSequence and LinksPrimersMalaCardsCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr6:33,289,597-33,290,934)mRNA (may differ from genome)Protein (129 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards
HGNCHPRDLynxMalacardsMGIOMIM
PubMedUniProtKBWikipediaBioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: PFDN6
Diseases sorted by gene-association score: corneal dystrophy (3), corneal dystrophy, thiel-behnke type (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 87.87 RPKM in Testis
Total median expression: 2024.38 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -30.50119-0.256 Picture PostScript Text
3' UTR -14.8089-0.166 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR002777 - PFD_beta-like
IPR009053 - Prefoldin

Pfam Domains:
PF01920 - Prefoldin subunit

ModBase Predicted Comparative 3D Structure on Q5STK2
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0051082 unfolded protein binding

Biological Process:
GO:0006457 protein folding

Cellular Component:
GO:0016272 prefoldin complex


-  Descriptions from all associated GenBank mRNAs
  LF210790 - JP 2014500723-A/18293: Polycomb-Associated Non-Coding RNAs.
MA446367 - JP 2018138019-A/18293: Polycomb-Associated Non-Coding RNAs.
AK312150 - Homo sapiens cDNA, FLJ92435, Homo sapiens HLA class II region expressed gene KE2 (HKE2), mRNA.
BC039033 - Homo sapiens prefoldin subunit 6, mRNA (cDNA clone MGC:47665 IMAGE:5748799), complete cds.
BC059783 - Homo sapiens prefoldin subunit 6, mRNA (cDNA clone MGC:70744 IMAGE:5415221), complete cds.
LF341226 - JP 2014500723-A/148729: Polycomb-Associated Non-Coding RNAs.
MA576803 - JP 2018138019-A/148729: Polycomb-Associated Non-Coding RNAs.
LF341225 - JP 2014500723-A/148728: Polycomb-Associated Non-Coding RNAs.
MA576802 - JP 2018138019-A/148728: Polycomb-Associated Non-Coding RNAs.
LF341224 - JP 2014500723-A/148727: Polycomb-Associated Non-Coding RNAs.
MA576801 - JP 2018138019-A/148727: Polycomb-Associated Non-Coding RNAs.
LF341223 - JP 2014500723-A/148726: Polycomb-Associated Non-Coding RNAs.
MA576800 - JP 2018138019-A/148726: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: DADB-159G18.5-004, DAMC-227D19.11-004, DAQB-193B15.2-001, ENST00000374607.1, ENST00000374607.2, ENST00000374607.3, ENST00000374607.4, hCG_17527, NM_014260, Q5STK2, Q5STK2_HUMAN, uc003odt.1, uc003odt.2
UCSC ID: ENST00000374607.5
RefSeq Accession: NM_014260
Protein: Q5STK2 CCDS: CCDS4773.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.